Development and application of an NMR-based assay for polyphenol oxidases

Show simple item record Li, Yu en Zafar, A en Kilmartin, Paul en Reynisson, Johannes en Leung, K en 2018-10-15T21:13:28Z en 2017-11 en
dc.identifier.issn 2365-6549 en
dc.identifier.uri en
dc.description.abstract Polyphenol oxidases (PPOs) are enzymes that catalyse the oxidation of phenolic compounds. We report a NMR-based assay that can be used as a screening and validation tool for PPO activity modulators, which was demonstrated using a series of PPO inhibitors and antioxidants. This method is exemplified by work in tandem with virtual screening and molecular modelling, which led to the discovery of several novel PPO inhibitors. en
dc.publisher Wiley en
dc.relation.ispartofseries ChemistrySelect en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Development and application of an NMR-based assay for polyphenol oxidases en
dc.type Journal Article en
dc.identifier.doi 10.1002/slct.201702144 en
pubs.issue 32 en
pubs.begin-page 10435 en
pubs.volume 2 en
dc.rights.holder Copyright: The author en en
pubs.end-page 10441 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 712273 en Science en Chemistry en Science Research en Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2017-11-14 en 2017-11-13 en

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