Development and application of an NMR-based assay for polyphenol oxidases

Li, Yu; Zafar, A; Kilmartin, Paul; Reynisson, Johannes; Leung, K

dc.contributor.author	Li, Yu	en
dc.contributor.author	Zafar, A	en
dc.contributor.author	Kilmartin, Paul	en
dc.contributor.author	Reynisson, Johannes	en
dc.contributor.author	Leung, K	en
dc.date.accessioned	2018-10-15T21:13:28Z	en
dc.date.issued	2017-11	en
dc.identifier.issn	2365-6549	en
dc.identifier.uri	http://hdl.handle.net/2292/41784	en
dc.description.abstract	Polyphenol oxidases (PPOs) are enzymes that catalyse the oxidation of phenolic compounds. We report a NMR-based assay that can be used as a screening and validation tool for PPO activity modulators, which was demonstrated using a series of PPO inhibitors and antioxidants. This method is exemplified by work in tandem with virtual screening and molecular modelling, which led to the discovery of several novel PPO inhibitors.	en
dc.publisher	Wiley	en
dc.relation.ispartofseries	ChemistrySelect	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	Development and application of an NMR-based assay for polyphenol oxidases	en
dc.type	Journal Article	en
dc.identifier.doi	10.1002/slct.201702144	en
pubs.issue	32	en
pubs.begin-page	10435	en
pubs.volume	2	en
dc.rights.holder	Copyright: The author	en
pubs.author-url	http://dx.doi.org/10.1002/slct.201702144	en
pubs.end-page	10441	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	712273	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2017-11-14	en
pubs.online-publication-date	2017-11-13	en