dc.contributor.author |
Guldenmund, P |
en |
dc.contributor.author |
Vanhaudenhuyse, A |
en |
dc.contributor.author |
Sanders, RD |
en |
dc.contributor.author |
Sleigh, James |
en |
dc.contributor.author |
Bruno, MA |
en |
dc.contributor.author |
Demertzi, A |
en |
dc.contributor.author |
Bahri, MA |
en |
dc.contributor.author |
Jaquet, O |
en |
dc.contributor.author |
Sanfilippo, J |
en |
dc.contributor.author |
Baquero, K |
en |
dc.contributor.author |
Boly, M |
en |
dc.contributor.author |
Brichant, JF |
en |
dc.contributor.author |
Laureys, S |
en |
dc.contributor.author |
Bonhomme, V |
en |
dc.date.accessioned |
2018-10-15T21:30:51Z |
en |
dc.date.issued |
2017-10 |
en |
dc.identifier.issn |
0007-0912 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/41803 |
en |
dc.description.abstract |
Background:We used functional connectivity measures from brain resting state functional magnetic resonance imaging to identify human neural correlates of sedation with dexmedetomidine or propofol and their similarities with natural sleep. Methods:Connectivity within the resting state networks that are proposed to sustain consciousness generation was compared between deep non-rapid-eye-movement (N3) sleep, dexmedetomidine sedation, and propofol sedation in volunteers who became unresponsive to verbal command. A newly acquired dexmedetomidine dataset was compared with our previously published propofol and N3 sleep datasets. Results:In all three unresponsive states (dexmedetomidine sedation, propofol sedation, and N3 sleep), within-network functional connectivity, including thalamic functional connectivity in the higher-order (default mode, executive control, and salience) networks, was significantly reduced as compared with the wake state. Thalamic functional connectivity was not reduced for unresponsive states within lower-order (auditory, sensorimotor, and visual) networks. Voxel-wise statistical comparisons between the different unresponsive states revealed that thalamic functional connectivity with the medial prefrontal/anterior cingulate cortex and with the mesopontine area was reduced least during dexmedetomidine-induced unresponsiveness and most during propofol-induced unresponsiveness. The reduction seen during N3 sleep was intermediate between those of dexmedetomidine and propofol. Conclusions:Thalamic connectivity with key nodes of arousal and saliency detection networks was relatively preserved during N3 sleep and dexmedetomidine-induced unresponsiveness as compared to propofol. These network effects may explain the rapid recovery of oriented responsiveness to external stimulation seen under dexmedetomidine sedation. Trial registry number:Committee number: 'Comité d'Ethique Hospitalo-Facultaire Universitaire de Liège' (707); EudraCT number: 2012-003562-40; internal reference: 20121/135; accepted on August 31, 2012; Chair: Prof G. Rorive. As it was considered a phase I clinical trial, this protocol does not appear on the EudraCT public website. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
BJA: British Journal of Anaesthesia |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Brain |
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dc.subject |
Neural Pathways |
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dc.subject |
Humans |
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dc.subject |
Propofol |
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dc.subject |
Dexmedetomidine |
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dc.subject |
Anesthetics, Intravenous |
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dc.subject |
Hypnotics and Sedatives |
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dc.subject |
Magnetic Resonance Imaging |
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dc.subject |
Brain Mapping |
en |
dc.subject |
Consciousness |
en |
dc.subject |
Sleep |
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dc.subject |
Image Processing, Computer-Assisted |
en |
dc.subject |
Adolescent |
en |
dc.subject |
Adult |
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dc.subject |
Female |
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dc.subject |
Male |
en |
dc.subject |
Young Adult |
en |
dc.title |
Brain functional connectivity differentiates dexmedetomidine from propofol and natural sleep. |
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dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1093/bja/aex257 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
674 |
en |
pubs.volume |
119 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
684 |
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pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
717938 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Anaesthesiology |
en |
dc.identifier.eissn |
1471-6771 |
en |
pubs.record-created-at-source-date |
2017-11-10 |
en |
pubs.dimensions-id |
29121293 |
en |