Human papillomavirus and oropharyngeal squamous cell carcinoma: a New Zealand cohort study.

Show simple item record Ou, Peter en Gear, Kim en Rahnama, Fahimeh en Thomas, Stephen en Nagappan, Radhika en Kee, Dennis en Waldvogel-Thurlow, Sharon en Jain, Ravi en McIvor, Nick en Izzard, Mark en Douglas, Richard en 2018-10-16T19:31:20Z en 2018-04 en
dc.identifier.issn 1445-1433 en
dc.identifier.uri en
dc.description.abstract BACKGROUND:Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCC) are clinically, epidemiologically and prognostically distinct from other OPSCCs. The incidence of HPV-related OPSCCs has increased significantly worldwide over the past few decades. However, no studies of OPSCC with direct molecular HPV testing has been conducted in New Zealand. AIMS:To estimate the proportion of OPSCCs attributable to HPV infections in a New Zealand population with a validated HPV testing algorithm. METHODS:HPV-status was determined by p16 immunohistochemistry and polymerase chain reaction (PCR) of both L1 and E6/7 genes on 55 OPSCCs diagnosed in 2010 and 2011 in Central and South Auckland. Baseline and survival analyses were performed according to HPV status. RESULTS:Forty-one (75%) of OPSCC tumours had HPV infections. There was 98% concordance between p16 immunohistochemistry and real-time E6/E7 PCR. After a median follow-up period of 2.6 years, patients with OPSCC of HPV aetiology had more favourable outcomes compared to patients with HPV-negative OPSCC (hazard ratio 0.14, P = 0.02) after adjustment for other variables. CONCLUSION:This study highlights the significant role that HPV plays in the aetiology of OPSCC in New Zealand, and confirms the high rate of accuracy of p16 immunostaining. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries ANZ journal of surgery en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Humans en
dc.subject Papillomaviridae en
dc.subject Papillomavirus Infections en
dc.subject Carcinoma, Squamous Cell en
dc.subject Oropharyngeal Neoplasms en
dc.subject Incidence en
dc.subject Survival Rate en
dc.subject Cohort Studies en
dc.subject Feasibility Studies en
dc.subject Algorithms en
dc.subject Adult en
dc.subject Aged en
dc.subject Middle Aged en
dc.subject New Zealand en
dc.subject Female en
dc.subject Male en
dc.subject Cyclin-Dependent Kinase Inhibitor p16 en
dc.subject Biomarkers en
dc.title Human papillomavirus and oropharyngeal squamous cell carcinoma: a New Zealand cohort study. en
dc.type Journal Article en
dc.identifier.doi 10.1111/ans.13759 en
pubs.issue 4 en
pubs.begin-page E278 en
pubs.volume 88 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 27647686 en
pubs.end-page E283 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.elements-id 542069 en Medical and Health Sciences en School of Medicine en Surgery Department en
dc.identifier.eissn 1445-2197 en
pubs.record-created-at-source-date 2016-09-21 en
pubs.dimensions-id 27647686 en

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