Intensity-Corrected Dual-Echo Echo-Planar Imaging (DE-EPI) for Improved Pediatric Brain Diffusion Imaging.

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dc.contributor.author Yeom, Kristen W en
dc.contributor.author Straka, Matus en
dc.contributor.author Iv, Michael en
dc.contributor.author Moseley, Michael E en
dc.contributor.author Barnes, Patrick D en
dc.contributor.author Skare, Stefan en
dc.contributor.author Holdsworth, Samantha en
dc.date.accessioned 2018-10-16T21:18:08Z en
dc.date.issued 2015-01 en
dc.identifier.citation PLoS One 10(6) Article number e0129325 12 Jun 2015 en
dc.identifier.issn 1932-6203 en
dc.identifier.uri http://hdl.handle.net/2292/42067 en
dc.description.abstract Here we investigate the utility of a dual-echo Echo-Planar Imaging (DE-EPI) Diffusion Weighted Imaging (DWI) approach to improve lesion conspicuity in pediatric imaging. This method delivers two 'echo images' for one diffusion-preparation period. We also demonstrate how the echoes can be utilized to remove transmit/receive coil-induced and static magnetic field intensity modulations on both echo images, which often mimic pathology and thereby pose diagnostic challenges. DE-EPI DWI data were acquired in 18 pediatric patients with abnormal diffusion lesions, and 46 pediatric patient controls at 3T. Echo1 [TE = 45ms] and Echo2 [TE = 86ms] were corrected for signal intensity variation across the images by exploiting the images equivalent coil-sensitivity and susceptibility-induced modulations. Two neuroradiologists independently reviewed Echo1 and Echo2 and their intensity-corrected variants (cEcho1 and cEcho2) on a 7-point Likert scale, with grading on lesion conspicuity diagnostic confidence. The apparent diffusion coefficient (ADC) map from Echo1 was used to validate presence of true pathology. Echo2 was unanimously favored over Echo1 for its sensitivity for detecting acute brain injury, with a mean respective lesion conspicuity of 5.7/4.4 (p < 0.005) and diagnostic confidence of 5.1/4.3 (p = 0.025). cEcho2 was rated higher than cEcho1, with a mean respective lesion conspicuity of 5.5/4.3 (p < 0.005) and diagnostic confidence of 5.4/4.4 (p < 0.005). cEcho2 was favored over all echoes for its diagnostic reliability, particularly in regions close to the head coil. This work concludes that DE-EPI DWI is a useful alternative to conventional single-echo EPI DWI, whereby Echo2 and cEcho2 allows for improved lesion detection and overall higher diagnostic confidence. en
dc.format.medium Electronic-eCollection en
dc.language eng en
dc.relation.ispartofseries PloS one en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Humans en
dc.subject Diffusion Magnetic Resonance Imaging en
dc.subject Image Enhancement en
dc.subject Echoencephalography en
dc.subject Adolescent en
dc.subject Child en
dc.subject Child, Preschool en
dc.subject Infant en
dc.subject Infant, Newborn en
dc.subject Female en
dc.subject Male en
dc.subject Multimodal Imaging en
dc.title Intensity-Corrected Dual-Echo Echo-Planar Imaging (DE-EPI) for Improved Pediatric Brain Diffusion Imaging. en
dc.type Journal Article en
dc.identifier.doi 10.1371/journal.pone.0129325 en
pubs.issue 6 en
pubs.begin-page e0129325 en
pubs.volume 10 en
dc.rights.holder Copyright: The authors en
dc.identifier.pmid 26069959 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Comparative Study en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.subtype Research Support, N.I.H., Extramural en
pubs.elements-id 683318 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Anatomy and Medical Imaging en
dc.identifier.eissn 1932-6203 en
pubs.record-created-at-source-date 2015-06-13 en
pubs.dimensions-id 26069959 en


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https://creativecommons.org/licenses/by/4.0/ Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/

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