dc.contributor.author |
Kersten, Hannah |
en |
dc.contributor.author |
Roxburgh, Richard |
en |
dc.contributor.author |
Danesh-Meyer, Helen |
en |
dc.date.accessioned |
2018-10-16T21:47:34Z |
en |
dc.date.issued |
2014-06 |
en |
dc.identifier.issn |
1759-4758 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42091 |
en |
dc.description.abstract |
Ophthalmic findings are common features of neurodegenerative disorders and, in addition to being clinically important, have emerged as potentially useful biomarkers of disease progression in several conditions. Clinically, these visual system abnormalities can be a clue to diagnosis, as well as being a prominent cause of disability in affected patients. In this Review, we describe the various afferent visual system and other ophthalmic features of inherited neurodegenerative disorders, including the muscular dystrophies, Friedreich ataxia, the spinocerebellar ataxias, hereditary spastic paraplegia, Charcot-Marie-Tooth disease, and other conditions. We focus on the expanding role of optical coherence tomography in diagnostic imaging of the retina and optic nerve head, and the possible use of ophthalmic findings as biomarkers of disease severity in hereditary neurodegenerative disorders. In addition, we discuss the ophthalmic manifestations and treatment implications of mitochondrial dysfunction, which is a feature of many inherited neurodegenerative diseases. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Nature reviews. Neurology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Optic Nerve |
en |
dc.subject |
Retina |
en |
dc.subject |
Humans |
en |
dc.subject |
Neurodegenerative Diseases |
en |
dc.subject |
Vision Disorders |
en |
dc.title |
Ophthalmic manifestations of inherited neurodegenerative disorders. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1038/nrneurol.2014.79 |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
349 |
en |
pubs.volume |
10 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
24840976 |
en |
pubs.end-page |
362 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
439829 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Ophthalmology Department |
en |
dc.identifier.eissn |
1759-4766 |
en |
pubs.record-created-at-source-date |
2014-06-06 |
en |
pubs.dimensions-id |
24840976 |
en |