dc.contributor.author |
Yozu, Hye-Won |
en |
dc.contributor.author |
Kilfoyle, DH |
en |
dc.contributor.author |
Hill, AG |
en |
dc.contributor.author |
Jameson, Michael |
en |
dc.contributor.author |
McKeage, Mark |
en |
dc.date.accessioned |
2018-10-16T22:13:48Z |
en |
dc.date.issued |
2016-12 |
en |
dc.identifier.issn |
1742-5255 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42142 |
en |
dc.description.abstract |
INTRODUCTION: Oxaliplatin-based chemotherapy has become the standard treatment for colorectal cancer and other gastrointestinal tumor types. Oxaliplatin-induced neurotoxicity is a major treatment-limiting side effect that compromizes the delivery of cancer treatment and causes long-standing neurological deficits that negatively impact upon patient quality of life Areas covered: The prevention of oxaliplatin-induced neurotoxicity represents an important opportunity for new therapeutic product development to address this major unmet medical need. In this article, we describe a phase Ib clinical trial design, and study procedures and protocols, that we have developed and now propose for the early clinical evaluation of investigational therapeutics for preventing oxaliplatin-induced neurotoxicity. Expert opinion: Recently, several advances have been made in the development of research methodologies applicable to the clinical evaluation of investigational drugs for preventing oxaliplatin-induced neurotoxicity. As we gain better understanding of the mechanisms of oxaliplatin-induced neurotoxicity, we will be able to use these methods to develop and test more effective and targeted neuroprotective agents that may not only improve patients' quality of life but also improve treatment delivery and survival outcomes |
en |
dc.publisher |
Ashley Publications Ltd. |
en |
dc.relation.ispartofseries |
Expert Opinion on Drug Metabolism and Toxicology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Preventing oxaliplatin-induced neurotoxicity: rationale and design of phase Ib randomized, double-blind, placebo-controlled, cross-over trials for early clinical evaluation of investigational therapeutics |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1080/17425255.2016.1223625 |
en |
pubs.issue |
12 |
en |
pubs.begin-page |
1479 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
27539508 |
en |
pubs.end-page |
1490 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
540590 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Waikato Clinical school |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2016-12-19 |
en |
pubs.dimensions-id |
27539508 |
en |