dc.contributor.author |
Thornley, Simon |
en |
dc.contributor.author |
Marshall, Roger |
en |
dc.contributor.author |
Jarrett, Paul |
en |
dc.contributor.author |
McDonald-Sundborn, Gerhard |
en |
dc.contributor.author |
Reynolds, Edwin |
en |
dc.contributor.author |
Schofield, Grant |
en |
dc.date.accessioned |
2018-10-17T00:06:50Z |
en |
dc.date.issued |
2018-06 |
en |
dc.identifier.issn |
1440-1754 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42262 |
en |
dc.description.abstract |
AIM:This study sought to determine whether scabies infection is associated with acute rheumatic fever (ARF) or chronic rheumatic heart disease (CRHD). METHODS:A cohort study was undertaken using health records of children aged 3-12 years attending an oral health service for the first time. Subjects were then linked to hospital diagnoses of scabies and ARF or CRHD. RESULTS:A total of 213 957 children free of rheumatic heart disease at baseline were available for analysis. During a mean follow-up time of 5.1 years, 440 children were diagnosed with ARF or CRHD in hospital records. Children diagnosed with scabies during follow-up were 23 times more likely to develop ARF or CRHD, compared with children who had no scabies diagnosis. After adjustment for confounders in a Cox model, the association reduced but remained strong (adjusted hazard ratio: 8.98; 95% confidence interval: 6.33-20.2). In an analysis restricted to children hospitalised at least once during follow-up, the adjusted hazard ratio for the same comparison was 3.43 (95% confidence interval: 1.85-6.37). CONCLUSIONS:A recent diagnosis of scabies from hospital records is strongly associated with a subsequent diagnosis of ARF. Further investigation of the role that scabies infestation may play in the aetiology of ARF is warranted. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Journal of paediatrics and child health |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Rheumatic Fever |
en |
dc.subject |
Scabies |
en |
dc.subject |
Dental Records |
en |
dc.subject |
Proportional Hazards Models |
en |
dc.subject |
Cohort Studies |
en |
dc.subject |
Child |
en |
dc.subject |
Child, Preschool |
en |
dc.subject |
New Zealand |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.title |
Scabies is strongly associated with acute rheumatic fever in a cohort study of Auckland children. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/jpc.13851 |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
625 |
en |
pubs.volume |
54 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
29442387 |
en |
pubs.end-page |
632 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
725278 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Population Health |
en |
pubs.org-id |
Epidemiology & Biostatistics |
en |
pubs.org-id |
Pacific Health |
en |
dc.identifier.eissn |
1440-1754 |
en |
pubs.record-created-at-source-date |
2018-02-15 |
en |
pubs.dimensions-id |
29442387 |
en |