dc.contributor.author |
Culliney, Katherine |
en |
dc.contributor.author |
McCowan, Lesley |
en |
dc.contributor.author |
Gafa, Cathryn |
en |
dc.contributor.author |
Murphy, Rinki |
en |
dc.contributor.author |
Rowan, Janet |
en |
dc.contributor.author |
Taylor, Rennae |
en |
dc.contributor.author |
McKinlay, Christopher |
en |
dc.contributor.author |
HUMBA Study Group |
en |
dc.date.accessioned |
2018-10-17T00:14:43Z |
en |
dc.date.issued |
2018-12 |
en |
dc.identifier.issn |
0004-8666 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42278 |
en |
dc.description.abstract |
BACKGROUND:In New Zealand, it is recommended that all pregnant women have a haemoglobin A1c (HbA1c) test performed with their booking antenatal bloods to identify previously unrecognised diabetes. However, screening rates in some groups are low. Use of a point-of-care device may improve compliance with screening. AIM:To assess the accuracy of the COBAS b101 point-of-care system referenced against a laboratory method, for measurement of HbA1c levels in pregnant women. MATERIALS AND METHODS:Convenience sample of 40 obese pregnant women enrolled in a clinical trial. HbA1c was assayed in paired capillary and venous whole blood samples using the COBAS b101 point-of-care system and Primus Ultra2 high performance liquid chromatography laboratory analyser, respectively. The accuracy of the point-of-care system was assessed by Bland-Altman analysis. RESULTS:The mean (SD) laboratory HbA1c was 35.9 (2.0) mmol/mol. The COBAS b101 point-of-care system, compared with the laboratory reference method, had a small negative bias for HbA1c (-1.0 mmol/mol, 95% CI -2.0 to -0.03, P = 0.03) and relatively wide 95% limits of agreement (-7.2 to 5.1 mmol/mol). CONCLUSION:In conclusion, we found that in pregnancy, the COBAS b101 point-of-care system has a small negative bias and modest point accuracy for HbA1c. When used to screen for previously unrecognised diabetes in pregnancy, appropriate COBAS b101 HbA1c point-of-care HbA1c thresholds for a negative and positive result are 7 mmol/mol below and 5 mmol/mol above the clinical threshold, respectively. Values between these limits should be confirmed by laboratory testing. |
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dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
The Australian & New Zealand journal of obstetrics & gynaecology |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
HUMBA Study Group |
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dc.subject |
Humans |
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dc.subject |
Diabetes, Gestational |
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dc.subject |
Diabetes Mellitus |
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dc.subject |
Mass Screening |
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dc.subject |
Prenatal Care |
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dc.subject |
Clinical Laboratory Techniques |
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dc.subject |
Reproducibility of Results |
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dc.subject |
Pregnancy |
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dc.subject |
Adult |
en |
dc.subject |
Point-of-Care Systems |
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dc.subject |
Female |
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dc.subject |
Young Adult |
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dc.subject |
Point-of-Care Testing |
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dc.subject |
Glycated Hemoglobin A |
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dc.title |
Accuracy of point-of-care HbA1c testing in pregnant women. |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1111/ajo.12786 |
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pubs.issue |
6 |
en |
pubs.begin-page |
643 |
en |
pubs.volume |
58 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
29468638 |
en |
pubs.end-page |
647 |
en |
pubs.publication-status |
Published |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
726752 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1479-828X |
en |
pubs.record-created-at-source-date |
2018-02-23 |
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pubs.dimensions-id |
29468638 |
en |