Accuracy of point-of-care HbA1c testing in pregnant women.

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dc.contributor.author Culliney, Katherine en
dc.contributor.author McCowan, Lesley en
dc.contributor.author Gafa, Cathryn en
dc.contributor.author Murphy, Rinki en
dc.contributor.author Rowan, Janet en
dc.contributor.author Taylor, Rennae en
dc.contributor.author McKinlay, Christopher en
dc.contributor.author HUMBA Study Group en
dc.date.accessioned 2018-10-17T00:14:43Z en
dc.date.issued 2018-12 en
dc.identifier.issn 0004-8666 en
dc.identifier.uri http://hdl.handle.net/2292/42278 en
dc.description.abstract BACKGROUND:In New Zealand, it is recommended that all pregnant women have a haemoglobin A1c (HbA1c) test performed with their booking antenatal bloods to identify previously unrecognised diabetes. However, screening rates in some groups are low. Use of a point-of-care device may improve compliance with screening. AIM:To assess the accuracy of the COBAS b101 point-of-care system referenced against a laboratory method, for measurement of HbA1c levels in pregnant women. MATERIALS AND METHODS:Convenience sample of 40 obese pregnant women enrolled in a clinical trial. HbA1c was assayed in paired capillary and venous whole blood samples using the COBAS b101 point-of-care system and Primus Ultra2 high performance liquid chromatography laboratory analyser, respectively. The accuracy of the point-of-care system was assessed by Bland-Altman analysis. RESULTS:The mean (SD) laboratory HbA1c was 35.9 (2.0) mmol/mol. The COBAS b101 point-of-care system, compared with the laboratory reference method, had a small negative bias for HbA1c (-1.0 mmol/mol, 95% CI -2.0 to -0.03, P = 0.03) and relatively wide 95% limits of agreement (-7.2 to 5.1 mmol/mol). CONCLUSION:In conclusion, we found that in pregnancy, the COBAS b101 point-of-care system has a small negative bias and modest point accuracy for HbA1c. When used to screen for previously unrecognised diabetes in pregnancy, appropriate COBAS b101 HbA1c point-of-care HbA1c thresholds for a negative and positive result are 7 mmol/mol below and 5 mmol/mol above the clinical threshold, respectively. Values between these limits should be confirmed by laboratory testing. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries The Australian & New Zealand journal of obstetrics & gynaecology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject HUMBA Study Group en
dc.subject Humans en
dc.subject Diabetes, Gestational en
dc.subject Diabetes Mellitus en
dc.subject Mass Screening en
dc.subject Prenatal Care en
dc.subject Clinical Laboratory Techniques en
dc.subject Reproducibility of Results en
dc.subject Pregnancy en
dc.subject Adult en
dc.subject Point-of-Care Systems en
dc.subject Female en
dc.subject Young Adult en
dc.subject Point-of-Care Testing en
dc.subject Glycated Hemoglobin A en
dc.title Accuracy of point-of-care HbA1c testing in pregnant women. en
dc.type Journal Article en
dc.identifier.doi 10.1111/ajo.12786 en
pubs.issue 6 en
pubs.begin-page 643 en
pubs.volume 58 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 29468638 en
pubs.end-page 647 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 726752 en
pubs.org-id Liggins Institute en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Obstetrics and Gynaecology en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1479-828X en
pubs.record-created-at-source-date 2018-02-23 en
pubs.dimensions-id 29468638 en


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