Spatio-temporal Organization During Ventricular Fibrillation in the Human Heart.

Show simple item record Robson, Jinny en Aram, Parham en Nash, Martyn en Bradley, Christopher en Hayward, Martin en Paterson, David J en Taggart, Peter en Clayton, Richard H en Kadirkamanathan, Visakan en 2018-10-17T01:33:57Z en 2018-06 en
dc.identifier.citation Annals of biomedical engineering 46(6):864-876 Jun 2018 en
dc.identifier.issn 0090-6964 en
dc.identifier.uri en
dc.description.abstract In this paper, we present a novel approach to quantify the spatio-temporal organization of electrical activation during human ventricular fibrillation (VF). We propose three different methods based on correlation analysis, graph theoretical measures and hierarchical clustering. Using the proposed approach, we quantified the level of spatio-temporal organization during three episodes of VF in ten patients, recorded using multi-electrode epicardial recordings with 30 s coronary perfusion, 150 s global myocardial ischaemia and 30 s reflow. Our findings show a steady decline in spatio-temporal organization from the onset of VF with coronary perfusion. We observed transient increases in spatio-temporal organization during global myocardial ischaemia. However, the decline in spatio-temporal organization continued during reflow. Our results were consistent across all patients, and were consistent with the numbers of phase singularities. Our findings show that the complex spatio-temporal patterns can be studied using complex network analysis. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Annals of biomedical engineering en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Pericardium en
dc.subject Humans en
dc.subject Ventricular Fibrillation en
dc.subject Myocardial Ischemia en
dc.subject Electrophysiologic Techniques, Cardiac en
dc.subject Female en
dc.subject Male en
dc.title Spatio-temporal Organization During Ventricular Fibrillation in the Human Heart. en
dc.type Journal Article en
dc.identifier.doi 10.1007/s10439-018-2007-9 en
pubs.issue 6 en
pubs.begin-page 864 en
pubs.volume 46 en
dc.rights.holder Copyright: The authors en
dc.identifier.pmid 29546467 en
pubs.end-page 876 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 732381 en Bioengineering Institute en ABI Associates en Engineering en Engineering Science en
dc.identifier.eissn 1573-9686 en
pubs.record-created-at-source-date 2018-03-17 en
pubs.dimensions-id 29546467 en

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