Omega-3 polyunsaturated fatty acid supplementation for improving peripheral nerve health: protocol for a systematic review.

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dc.contributor.author Zhang, Alexis Ceecee en
dc.contributor.author MacIsaac, Richard J en
dc.contributor.author Roberts, Leslie en
dc.contributor.author Kamel, Jordan en
dc.contributor.author Craig, Jennifer en
dc.contributor.author Busija, Lucy en
dc.contributor.author Downie, Laura E en
dc.date.accessioned 2018-10-17T01:40:55Z en
dc.date.issued 2018-03-25 en
dc.identifier.issn 2044-6055 en
dc.identifier.uri http://hdl.handle.net/2292/42404 en
dc.description.abstract INTRODUCTION:Damage to peripheral nerves occurs in a variety of health conditions. Preserving nerve integrity, to prevent progressive nerve damage, remains a clinical challenge. Omega-3 polyunsaturated fatty acids (PUFAs) are implicated in the development and maintenance of healthy nerves and may be beneficial for promoting peripheral nerve health. The aim of this systematic review is to assess the effects of oral omega-3 PUFA supplementation on peripheral nerve integrity, including both subjective and objective measures of peripheral nerve structure and/or function. METHODS AND ANALYSIS:A systematic review of randomised controlled trials that have evaluated the effects of omega-3 PUFA supplementation on peripheral nerve assessments will be conducted. Comprehensive electronic database searches will be performed in Ovid MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), US National Institutes of Health Clinical Trials Registry and the WHO International Clinical Trials Registry Platform. The title, abstract and keywords of identified articles will be assessed for eligibility by two reviewers. Full-text articles will be obtained for all studies judged as eligible or potentially eligible; these studies will be independently assessed by two reviewers to determine eligibility. Disagreements will be resolved by consensus. Risk of bias assessment will be performed using the Cochrane Collaboration risk of bias tool to appraise the quality of included studies. If clinically meaningful, and there are a sufficient number of eligible studies, a meta-analysis will be conducted and a summary of findings table will be provided. ETHICS AND DISSEMINATION:This is a systematic review that will involve the analysis of previously published data, and therefore ethics approval is not required. A manuscript reporting the results of this systematic review will be published in a peer-reviewed journal and may also be presented at relevant scientific conferences. PROSPERO REGISTRATION NUMBER:CRD42018086297. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries BMJ open en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/2044-6055/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ en
dc.subject Humans en
dc.subject Peripheral Nervous System Diseases en
dc.subject Fatty Acids, Omega-3 en
dc.subject Nutrition Therapy en
dc.subject Research Design en
dc.subject Dietary Supplements en
dc.subject Randomized Controlled Trials as Topic en
dc.subject Systematic Reviews as Topic en
dc.title Omega-3 polyunsaturated fatty acid supplementation for improving peripheral nerve health: protocol for a systematic review. en
dc.type Journal Article en
dc.identifier.doi 10.1136/bmjopen-2017-020804 en
pubs.issue 3 en
pubs.begin-page e020804 en
pubs.volume 8 en
dc.rights.holder Copyright: The authors en
dc.identifier.pmid 29581208 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype protocol en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 734736 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Ophthalmology Department en
dc.identifier.eissn 2044-6055 en
pubs.record-created-at-source-date 2018-03-28 en
pubs.dimensions-id 29581208 en


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