Exploring topical anti-glaucoma medication effects on the ocular surface in the context of the current understanding of dry eye.

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dc.contributor.author Wong, Aaron BC en
dc.contributor.author Wang, Michael en
dc.contributor.author Liu, Kevin en
dc.contributor.author Prime, Zak J en
dc.contributor.author Danesh-Meyer, Helen en
dc.contributor.author Craig, Jennifer en
dc.date.accessioned 2018-10-17T01:57:46Z en
dc.date.issued 2018-07 en
dc.identifier.issn 1542-0124 en
dc.identifier.uri http://hdl.handle.net/2292/42467 en
dc.description.abstract PURPOSE:To assess tear film parameters, ocular surface characteristics, and dry eye symptomology in patients receiving topical anti-glaucoma medications. METHODS:Thirty-three patients with a diagnosis of open angle glaucoma or ocular hypertension, receiving unilateral topical anti-glaucoma medication for at least 6 months, were recruited in a cross-sectional, investigator-masked, paired-eye comparison study. Tear film parameters, ocular surface characteristics, and dry eye symptomology of treated and fellow eyes were evaluated and compared. RESULTS:The mean ± SD age of the participants was 67 ± 12 years, and the mean ± SD treatment duration was 5.3 ± 4.4 years. Treated eyes had poorer non-invasive tear film breakup time (p = 0.03), tear film osmolarity (p = 0.04), bulbar conjunctival hyperaemia (p = 0.04), eyelid margin abnormality grade (p = 0.01), tear meniscus height (p = 0.03), and anaesthetised Schirmer value (p = 0.04) than fellow eyes. There were no significant differences in dry eye symptomology, meibomian gland assessments, and ocular surface staining between treated and fellow eyes (all p > 0.05). CONCLUSIONS:Adverse changes in tear film stability, tear osmolarity, conjunctival hyperaemia, and eyelid margins were observed in treated eyes. This suggests that inflammatory mechanisms may be implicated in the development of dry eye in patients receiving long term topical anti-glaucoma therapy. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries The ocular surface en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Conjunctiva en
dc.subject Meibomian Glands en
dc.subject Tears en
dc.subject Humans en
dc.subject Dry Eye Syndromes en
dc.subject Glaucoma en
dc.subject Antihypertensive Agents en
dc.subject Cross-Sectional Studies en
dc.subject Adult en
dc.subject Aged en
dc.subject Aged, 80 and over en
dc.subject Middle Aged en
dc.subject Female en
dc.subject Male en
dc.title Exploring topical anti-glaucoma medication effects on the ocular surface in the context of the current understanding of dry eye. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jtos.2018.03.002 en
pubs.issue 3 en
pubs.begin-page 289 en
pubs.volume 16 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 29510226 en
pubs.end-page 293 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 732168 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Ophthalmology Department en
dc.identifier.eissn 1937-5913 en
pubs.record-created-at-source-date 2018-03-07 en
pubs.dimensions-id 29510226 en

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