dc.contributor.author |
Dhillon, SK |
en |
dc.contributor.author |
Lear, Christopher |
en |
dc.contributor.author |
Galinsky, Robert |
en |
dc.contributor.author |
Wassink, Guido |
en |
dc.contributor.author |
Davidson, Joanne |
en |
dc.contributor.author |
Juul, S |
en |
dc.contributor.author |
Robertson, NJ |
en |
dc.contributor.author |
Gunn, Alistair |
en |
dc.contributor.author |
Bennet, Laura |
en |
dc.date.accessioned |
2018-10-17T02:01:51Z |
en |
dc.date.issued |
2018-05-17 |
en |
dc.identifier.issn |
0022-3751 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42482 |
en |
dc.description.abstract |
Brain injury around birth is associated with nearly half of all cases of cerebral palsy. Although brain injury is multifactorial, particularly after preterm birth, acute hypoxia-ischaemia is a major contributor to injury. It is now well established that the severity of injury after hypoxia-ischaemia is determined by a dynamic balance between injurious and protective processes. In addition, mothers who are at risk of premature delivery have high rates of diabetes and antepartum infection/inflammation and are almost universally given treatments such as antenatal glucocorticoids and magnesium sulphate to reduce the risk of death and complications after preterm birth. We review evidence that these common factors affect responses to fetal asphyxia, often in unexpected ways. For example, glucocorticoid exposure dramatically increases delayed cell loss after acute hypoxia-ischaemia, largely through secondary hyperglycaemia. This critical new information is important to understand the effects of clinical treatments of women whose fetuses are at risk of perinatal asphyxia. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
Wiley |
en |
dc.relation.ispartofseries |
The Journal of Physiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights |
This is the pre-peer reviewed version of the following article: [Dhillon SK, Lear CA, Galinsky R, Wassink G, Davidson JO, Juul S, Robertson NJ, Gunn AJ, Bennet L (2018) The fetus at the tipping point: modifying the outcome of fetal asphyxia, The Journal of physiology 596(23):5571-5592 , which has been published in final form at http://dx.doi.org/10.1113/jp274949. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html |
en |
dc.title |
The fetus at the tipping point: modifying the outcome of fetal asphyxia. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1113/jp274949 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
5571 |
en |
pubs.volume |
596 |
en |
dc.rights.holder |
Copyright: Wiley |
en |
dc.identifier.pmid |
29774532 |
en |
pubs.end-page |
5592 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Review |
en |
pubs.elements-id |
740905 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
dc.identifier.eissn |
1469-7793 |
en |
pubs.record-created-at-source-date |
2018-11-10 |
en |
pubs.dimensions-id |
29774532 |
en |