Defining low anterior resection syndrome: a systematic review of the literature.

Show simple item record Keane, Celia en Wells, C en O'Grady, Gregory en Bissett, Ian en 2018-10-17T22:41:28Z en 2017-08 en
dc.identifier.issn 1462-8910 en
dc.identifier.uri en
dc.description.abstract There is increasing awareness of the poor functional outcome suffered by many patients after sphincter-preserving rectal resection, termed 'low anterior resection syndrome' (LARS). There is no consensus definition of LARS and varying instruments have been employed to measure functional outcome, complicating research into prevalence, contributing factors and potential therapies. We therefore aimed to describe the instruments and outcome measures used in studies of bowel dysfunction after low anterior resection and identify major themes used in the assessment of LARS.A systematic review of the literature was performed for studies published between 1986 and 2016. The instruments and outcome measures used to report bowel function after low anterior resection were extracted and their frequency of use calculated.The search revealed 128 eligible studies. These employed 18 instruments, over 30 symptoms, and follow-up time periods from 4 weeks to 14.6 years. The most frequent follow-up period was 12 months (48%). The most frequently reported outcomes were incontinence (97%), stool frequency (80%), urgency (67%), evacuatory dysfunction (47%), gas-stool discrimination (34%) and a measure of quality of life (80%). Faecal incontinence scoring systems were used frequently. The LARS score and the Bowel Function Instrument (BFI) were used in only nine studies.LARS is common, but there is substantial variation in the reporting of functional outcomes after low anterior resection. Most studies have focused on incontinence, omitting other symptoms that correlate with patients' quality of life. To improve and standardize research into LARS, a consensus definition should be developed, and these findings should inform this goal. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Rectum en
dc.subject Humans en
dc.subject Rectal Diseases en
dc.subject Fecal Incontinence en
dc.subject Syndrome en
dc.subject Postoperative Complications en
dc.subject Treatment Outcome en
dc.subject Colectomy en
dc.subject Postoperative Period en
dc.subject Defecation en
dc.subject Quality of Life en
dc.subject Adult en
dc.subject Aged en
dc.subject Middle Aged en
dc.subject Anal Canal en
dc.subject Female en
dc.subject Male en
dc.subject Organ Sparing Treatments en
dc.subject Symptom Assessment en
dc.title Defining low anterior resection syndrome: a systematic review of the literature. en
dc.type Journal Article en
dc.identifier.doi 10.1111/codi.13767 en
pubs.issue 8 en
pubs.begin-page 713 en
pubs.volume 19 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 28612460 en
pubs.end-page 722 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 632412 en Bioengineering Institute en ABI Associates en Medical and Health Sciences en School of Medicine en Surgery Department en
dc.identifier.eissn 1463-1318 en
pubs.record-created-at-source-date 2017-06-15 en
pubs.dimensions-id 28612460 en

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