dc.contributor.author |
Meyer, Jay |
en |
dc.contributor.author |
Gokul, Akilesh |
en |
dc.contributor.author |
Crawford, Alexandra Z |
en |
dc.contributor.author |
McGhee, Charles |
en |
dc.date.accessioned |
2018-10-17T23:47:14Z |
en |
dc.date.issued |
2016-09 |
en |
dc.identifier.issn |
0002-9394 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42735 |
en |
dc.description.abstract |
To evaluate the long-term risk of endothelial rejection, graft survival, and associated factors following penetrating keratoplasty (PK) for keratoconus, with and without prior resolved corneal hydrops.Retrospective cohort study.Primary outcome measures were endothelial rejection-free survival and failure-free survival. Secondary outcome measures were corneal neovascularization following hydrops and complications following PK.A total of 245 eyes underwent PK for keratoconus with mean follow-up of 5.6 ± 3.6 years. Eyes with prior hydrops (n = 74) had lower endothelial rejection-free survival rates compared with eyes without prior hydrops: 86.5% ± 4.0% vs 86.5% ± 2.6% at 1 year, 61.0% ± 6.2% vs 76.9% ± 3.3% at 5 years, and 45.8% ± 10.1% vs 70.9% ± 4.3% at 10 years, respectively (P = .023). Multivariate analysis identified factors associated with endothelial rejection as age ≤25 years (P = .017), corneal neovascularization (P = .001), donor trephination size >8 mm (P = .017), and poor clinic attendance (P = .015). There was no difference in the failure-free survival rates with and without prior hydrops: 98.6% ± 1.3% vs 97.1% ± 1.3% at 1 year, 97.3% ± 1.9% vs 95.1% ± 1.9% at 5 years, and 97.3% ± 1.9% vs 92.2% ± 2.7% at 10 years, respectively (P = .42). Corneal neovascularization was present at the time of PK in 44.6% of eyes with prior hydrops and 7.6% without prior hydrops (P < .001).Corneal neovascularization, a frequent complication of corneal hydrops, was associated with increased risk of endothelial rejection following PK. However, allograft survival was similar in eyes with and without prior hydrops. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
American Journal of Ophthalmology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Corneal Edema |
en |
dc.subject |
Keratoconus |
en |
dc.subject |
Keratoplasty, Penetrating |
en |
dc.subject |
Retrospective Studies |
en |
dc.subject |
Cohort Studies |
en |
dc.subject |
Follow-Up Studies |
en |
dc.subject |
Graft Rejection |
en |
dc.subject |
Graft Survival |
en |
dc.subject |
Visual Acuity |
en |
dc.subject |
Adult |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Young Adult |
en |
dc.title |
Penetrating Keratoplasty for Keratoconus With and Without Resolved Corneal Hydrops: Long-term Results. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.ajo.2016.07.001 |
en |
pubs.begin-page |
282 |
en |
pubs.volume |
169 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
27422170 |
en |
pubs.end-page |
289 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
538077 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
dc.identifier.eissn |
1879-1891 |
en |
pubs.record-created-at-source-date |
2016-07-17 |
en |
pubs.dimensions-id |
27422170 |
en |