Medicated Ocular Bandages and Corneal Health: Potential Excipients and Active Pharmaceutical Ingredients

Show simple item record Zidan, G en Rupenthal, Ilva en Greene, Carol en Seyfoddin, A en 2018-10-17T23:50:51Z en 2017 en
dc.identifier.citation Pharmaceutical Development and Technology 23(3):255-260 16 Mar 2018 en
dc.identifier.issn 1083-7450 en
dc.identifier.uri en
dc.description.abstract Corneal blindness can occur due to improper healing of the corneal tissues after induced injury or abrasion which can be accidental, pathogenic, or after corneal surgery. Abnormal regulation of the healing mechanisms can lead to corneal opacity. Reducing inflammation and promoting epithelial wound healing are crucial for scar-free corneal recovery without eyesight complications. Current approaches for corneal wound healing involve amniotic membrane (AM) bandages, bandage contact lenses (BCL), and collagen shields in conjunction with frequent administration of therapeutic eye drops. The problem with eye drops is poor bioavailability and patient incompliance that might lead to corneal wound healing complications and poor clinical outcomes. Various methods have been proposed for loading drugs into medicated bandage lenses. There are advantages and limitations associated with each technique regarding the ease of manufacture, drug loading, release kinetics, and suitability with various therapeutics and hydrogel types. There is still, however, no drug-eluting corneal bandage on the market despite the need for such a convenient and cost-efficient strategy for corneal wound healing. This review will highlight materials and therapeutics that can be used in medicated ocular bandages and various ways of incorporating drugs, while discussing the limitations and challenges associated with bringing medicated ocular bandages in the market. en
dc.publisher Taylor & Francis en
dc.relation.ispartofseries Pharmaceutical Development and Technology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
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dc.title Medicated Ocular Bandages and Corneal Health: Potential Excipients and Active Pharmaceutical Ingredients en
dc.type Journal Article en
dc.identifier.doi 10.1080/10837450.2017.1377232 en
pubs.issue 3 en
pubs.begin-page 255 en
pubs.volume 23 en
dc.rights.holder Copyright: Taylor & Francis en
dc.identifier.pmid 28875742 en
pubs.end-page 260 en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 665157 en Medical and Health Sciences en School of Medicine en Ophthalmology Department en
pubs.record-created-at-source-date 2017-09-12 en 2017-09-06 en
pubs.dimensions-id 28875742 en

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