dc.contributor.author |
Gusso, Silmara |
en |
dc.contributor.author |
Pinto, Teresa |
en |
dc.contributor.author |
Baldi, James C |
en |
dc.contributor.author |
Behrensdorf Derraik, Jose |
en |
dc.contributor.author |
Cutfield, Wayne |
en |
dc.contributor.author |
Hornung, Tim |
en |
dc.contributor.author |
Hofman, Paul |
en |
dc.date.accessioned |
2018-10-18T01:25:43Z |
en |
dc.date.issued |
2017-09 |
en |
dc.identifier.issn |
0149-5992 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42789 |
en |
dc.description.abstract |
To determine the impact of 20 weeks of exercise training in aerobic capacity on left ventricular function and glycemic control in adolescents with and without type 1 diabetes.Fifty-three adolescents with type 1 diabetes (aged 15.6 years) were divided into two groups: exercise training (n = 38) and nontraining (n = 15). Twenty-two healthy adolescents without diabetes (aged 16.7 years) were included and, with the 38 participants with type 1 diabetes, participated in a 20-week exercise-training intervention. Assessments included VO2max and body composition. Left ventricular parameters were obtained at rest and during acute exercise using MRI.Exercise training improved aerobic capacity (10%) and stroke volume (6%) in both trained groups, but the increase in the group with type 1 diabetes remained lower than trained control subjects. Increased stroke volume in adolescents with type 1 diabetes resulted from greater left ventricular contractility (9% increase in ejection fraction and an 11% reduction in end-systolic volumes) and, to a lesser extent, improved left ventricular filling (6%), suggesting that impaired diastolic function can be affected by exercise training in adolescents with type 1 diabetes. Insulin use decreased by ∼10%, but no change in glycemic status was observed.These data demonstrate that in adolescents, the impairment in left ventricular function seen with type 1 diabetes can be improved, although not normalized, with regular intense physical activity. Importantly, diastolic dysfunction, a common mechanism causing heart failure in older subjects with diabetes, appears to be partially reversible in this age group. |
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dc.format.medium |
Print-Electronic |
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dc.language |
eng |
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dc.relation.ispartofseries |
Diabetes care |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Heart Ventricles |
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dc.subject |
Humans |
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dc.subject |
Diabetes Mellitus, Type 1 |
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dc.subject |
Blood Glucose |
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dc.subject |
Stroke Volume |
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dc.subject |
Exercise Therapy |
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dc.subject |
Body Composition |
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dc.subject |
Oxygen Consumption |
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dc.subject |
Blood Pressure |
en |
dc.subject |
Heart Rate |
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dc.subject |
Ventricular Function, Left |
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dc.subject |
Exercise Tolerance |
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dc.subject |
Rest |
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dc.subject |
Adolescent |
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dc.subject |
Female |
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dc.subject |
Male |
en |
dc.subject |
Arterial Pressure |
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dc.subject |
Glycated Hemoglobin A |
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dc.title |
Exercise Training Improves but Does Not Normalize Left Ventricular Systolic and Diastolic Function in Adolescents With Type 1 Diabetes. |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.2337/dc16-2347 |
en |
pubs.issue |
9 |
en |
pubs.begin-page |
1264 |
en |
pubs.volume |
40 |
en |
dc.rights.holder |
Copyright: The author |
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dc.identifier.pmid |
28720592 |
en |
pubs.end-page |
1272 |
en |
pubs.publication-status |
Published |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
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pubs.subtype |
Research Support, Non-U.S. Gov't |
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pubs.subtype |
Randomized Controlled Trial |
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pubs.subtype |
Journal Article |
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pubs.elements-id |
638794 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Paediatrics Child & Youth Hlth |
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pubs.org-id |
Science |
en |
pubs.org-id |
Exercise Sciences |
en |
dc.identifier.eissn |
1935-5548 |
en |
pubs.record-created-at-source-date |
2017-07-20 |
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pubs.dimensions-id |
28720592 |
en |