dc.contributor.author |
Gokul, Akilesh |
en |
dc.contributor.author |
Patel, Dipika |
en |
dc.contributor.author |
Watters, Grant |
en |
dc.contributor.author |
McGhee, Charles |
en |
dc.date.accessioned |
2018-10-18T01:56:56Z |
en |
dc.date.issued |
2017-06 |
en |
dc.identifier.issn |
0007-1161 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42823 |
en |
dc.description.abstract |
To determine if significant progression of disease occurs in older, non-contact lens wearing, subjects with keratoconus and to identify potential predictive factors.Clinical and computerised corneal topography records of subjects with keratoconus attending a specialist optometry practice were retrospectively analysed to identify those aged ≥30 years, with ≥2 consultations ≥12 months apart, no contact lens wear and no corneal scarring, surgery or corneal hydrops. Topographic parameters assessed included: maximum keratometry (Kmax), steep keratometry (Ksteep), flat keratometry (Kflat), inferior-superior (I-S) ratio and the surface asymmetry and regularity (surface asymmetry index and surface regularity index) indices.Of the 449 subjects with keratoconus assessed, 43 eyes of 27 patients (6.01%) met inclusion criteria, with median age 38.45 (12.86) years at baseline and median follow-up 4.36 (8.68) years. There was a significant increase in Kmax (0.30 (1.21) D), Ksteep (0.27 (0.90) D), Kflat (0.34 (1.12) D) and I-S (0.26 (0.82) D) between baseline and final review, p<0.05. Notably, 18.6%-25.6% of eyes demonstrated ≥1.00 D increase in one or more of four principal topographic parameters (Kmax, Ksteep, Kflat, I-S ratio), while 18.5%-37.0% of subjects had ≥1.00 D increase in the aforementioned parameters in at least one eye over the study period. However, <10% of eyes exhibited ≥1.00 D increase/year in all topographic parameters. The only significant predictor of progression was follow-up time.This study confirms that keratoconus may continue to progress beyond age 30. Older subjects with keratoconus should be monitored for progression, particularly with respect to possible corneal collagen cross-linking or astigmatic correction in cataract surgery. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
The British journal of ophthalmology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Cornea |
en |
dc.subject |
Humans |
en |
dc.subject |
Keratoconus |
en |
dc.subject |
Disease Progression |
en |
dc.subject |
Corneal Topography |
en |
dc.subject |
Retrospective Studies |
en |
dc.subject |
Follow-Up Studies |
en |
dc.subject |
Eyeglasses |
en |
dc.subject |
Visual Acuity |
en |
dc.subject |
Adult |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.title |
The natural history of corneal topographic progression of keratoconus after age 30 years in non-contact lens wearers. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1136/bjophthalmol-2016-308682 |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
839 |
en |
pubs.volume |
101 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
27729309 |
en |
pubs.end-page |
844 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
542799 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
dc.identifier.eissn |
1468-2079 |
en |
pubs.record-created-at-source-date |
2016-10-13 |
en |
pubs.dimensions-id |
27729309 |
en |