Low-level exposure to organophosphate pesticides leads to restrictive lung dysfunction.

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dc.contributor.author Peiris-John, Roshini en
dc.contributor.author Ruberu, Dawala Kusuma en
dc.contributor.author Wickremasinghe, Ananda Rajitha en
dc.contributor.author van-der-Hoek, Wim en
dc.date.accessioned 2018-10-18T23:28:40Z en
dc.date.issued 2005-10 en
dc.identifier.issn 0954-6111 en
dc.identifier.uri http://hdl.handle.net/2292/42883 en
dc.description.abstract Apart from symptomology, there are very few reports on lung function following exposure to low levels of organophosphate (OP) pesticides in man. Twenty-five occupationally exposed farmers and 22 environmentally exposed freshwater fishermen were evaluated between and during OP spray seasons. Forty marine fishermen living away from agricultural areas were recruited as a control group. Forced vital capacity (FVC) and forced expiratory volume in the first second (FEV(1)) were measured by spirometry. Haemoglobin corrected erythrocyte acetylcholinesterase (AChE) levels were measured during and between (baseline estimation) spray seasons using a portable WHO-approved Test-mate system (EQM Research, Ohio). FVC ratio was lower in the farmers as compared to the controls (P<0.001) between exposure seasons. In the farmers, FVC ratio decreased further during the exposure season (P=0.023). FEV(1) was lower in the farmers as compared to the controls in both periods (P<0.05). In the fishermen, the decrease in ratios of FVC and FEV(1) following exposure to pesticides was not significant. FEV(1)/FVC ratios were similar in the three groups between (P=0.988) and during (P=0.159) exposure periods. Following exposure to OPs, AChE levels dropped 12.75% in the farmers (P<0.001) and 5.62% in the freshwater fishermen (P=0.001). Occupational exposure to OP results in restrictive lung dysfunction, a phenomenon not observed following environmental exposure. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Respiratory Medicine en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Humans en
dc.subject Organophosphorus Compounds en
dc.subject Acetylcholinesterase en
dc.subject Biological Markers en
dc.subject Insecticides en
dc.subject Vital Capacity en
dc.subject Maximal Expiratory Flow Rate en
dc.subject Forced Expiratory Volume en
dc.subject Occupational Exposure en
dc.subject Agriculture en
dc.subject Fisheries en
dc.subject Adult en
dc.subject Sri Lanka en
dc.subject Male en
dc.title Low-level exposure to organophosphate pesticides leads to restrictive lung dysfunction. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.rmed.2005.02.001 en
pubs.issue 10 en
pubs.begin-page 1319 en
pubs.volume 99 en
dc.identifier.pmid 16102957 en
pubs.end-page 1324 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 272006 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Population Health en
pubs.org-id Epidemiology & Biostatistics en
dc.identifier.eissn 1532-3064 en
pubs.record-created-at-source-date 2005-09-05 en
pubs.dimensions-id 16102957 en

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