dc.contributor.author |
Asadi, Khalid |
en |
dc.contributor.author |
Ferguson, Lynnette |
en |
dc.contributor.author |
Philpott, Martin |
en |
dc.contributor.author |
Karunasinghe, Wannakuwattewaduge |
en |
dc.date.accessioned |
2018-10-18T23:38:27Z |
en |
dc.date.issued |
2017-09-30 |
en |
dc.identifier.issn |
2288-3649 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42894 |
en |
dc.description.abstract |
Anthocyanin-rich foods and preparations have been reported to reduce the risk of life-style related diseases, including cancer. The SL222 sweet potato, a purple-fleshed cultivar developed in New Zealand, accumulates high levels of anthocyanins in its storage root.We examined the chemopreventative properties of the SL222 sweet potato in the C57BL/6J-APC MIN/+ (APCMIN) mouse, a genetic model of colorectal cancer. APCMIN and C57BL/6J wild-type mice (n=160) were divided into four feeding groups consuming diets containing 10% SL222 sweet potato flesh, 10% SL222 sweet potato skin, or 0.12% ARE (Anthocyanin rich-extract prepared from SL222 sweet potato at a concentration equivalent to the flesh-supplemented diet) or a control diet (AIN-76A) for 18 weeks. At 120 days of age, the mice were anaesthetised, and blood samples were collected before the mice were sacrificed. The intestines were used for adenoma enumeration.The SL222 sweet potato-supplemented diets reduced the adenoma number in the APCMIN mice.These data have significant implications for the use of this sweet potato variant in protection against colorectal cancer. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Journal of Cancer Prevention |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APCMIN Mouse Model. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.15430/jcp.2017.22.3.135 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
135 |
en |
pubs.volume |
22 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
29018778 |
en |
pubs.end-page |
146 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
704661 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
dc.identifier.eissn |
2288-3657 |
en |
pubs.record-created-at-source-date |
2017-10-12 |
en |
pubs.dimensions-id |
29018778 |
en |