dc.contributor.author |
Leong, Karen |
en |
dc.contributor.author |
Behrensdorf Derraik, Jose |
en |
dc.contributor.author |
Hofman, Paul |
en |
dc.contributor.author |
Cutfield, Wayne |
en |
dc.date.accessioned |
2018-10-19T01:10:31Z |
en |
dc.date.issued |
2018-02 |
en |
dc.identifier.citation |
Clinical endocrinology 88(2):185-200 Feb 2018 |
en |
dc.identifier.issn |
0300-0664 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42931 |
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dc.description.abstract |
Antibiotics have been hailed by many as "miracle drugs" that have been effectively treating infectious diseases for over a century, leading to a marked reduction in morbidity and mortality. However, with the increasing use of antibiotics, we are now faced not only with the increasing threat of antibiotic resistance, but also with a rising concern about potential long-term effects of antibiotics on human health, including the development of obesity. The obesity pandemic continues to increase, a problem that affects both adults and children alike. Disruptions to the gut microbiome have been linked to a multitude of adverse conditions, including obesity, type 2 diabetes, inflammatory bowel diseases, anxiety, autism, allergies, and autoimmune diseases. This review focuses on the association between antibiotics and obesity, and the role of the gut microbiome. There is strong evidence supporting the role of antibiotics in the development of obesity in well-controlled animal models. However, evidence for this link in humans is still inconclusive, and we need further well-designed clinical trials to clarify this association. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
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dc.relation.ispartofseries |
Clinical endocrinology |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights |
This is the peer reviewed version of the following article: Leong, K. S. W., Derraik, J. G. B., Hofman, P. L., & Cutfield, W. S. (2018). Antibiotics, gut microbiome and obesity.. Clinical endocrinology, 88(2), 185-200, which has been published in final form at http://dx.doi.org/10.1111/cen.13495. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html |
en |
dc.subject |
Animals |
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dc.subject |
Obesity |
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dc.subject |
Anti-Bacterial Agents |
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dc.subject |
Models, Animal |
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dc.subject |
Gastrointestinal Microbiome |
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dc.title |
Antibiotics, gut microbiome and obesity. |
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dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/cen.13495 |
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pubs.issue |
2 |
en |
pubs.begin-page |
185 |
en |
pubs.volume |
88 |
en |
dc.rights.holder |
Copyright: Wiley |
en |
dc.identifier.pmid |
29023853 |
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pubs.end-page |
200 |
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pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
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pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
694476 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Paediatrics Child & Youth Hlth |
en |
dc.identifier.eissn |
1365-2265 |
en |
pubs.record-created-at-source-date |
2017-10-13 |
en |
pubs.dimensions-id |
29023853 |
en |