dc.contributor.author |
Misra, Stuti |
en |
dc.contributor.author |
Goh, Yi Wei |
en |
dc.contributor.author |
Patel, Dipika |
en |
dc.contributor.author |
Riley, Andrew F |
en |
dc.contributor.author |
McGhee, Charles |
en |
dc.date.accessioned |
2018-10-19T01:54:27Z |
en |
dc.date.issued |
2015-02 |
en |
dc.identifier.issn |
0277-3740 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/42960 |
en |
dc.description.abstract |
The aim of this study was to analyze microstructural corneal changes following phacoemulsification of cataract with intraocular lens insertion in diabetes mellitus (DM).Prospective study of consecutive patients undergoing phacoemulsification with intraocular lens insertion, over a period of 6 months. Age, gender, serum glycosylated hemoglobin A1c levels, and effective phacoemulsification time were recorded. Anterior segment optical coherence tomography and corneal in vivo confocal microscopy were performed preoperatively and 1-month postoperatively. Subbasal nerve plexus (SBN) density, basal epithelial cell density, and endothelial cell density (ECD) were quantitatively analyzed.Twenty-eight patients with type 2 DM (71.2 ± 7.6 years) and 23 healthy controls (mean age, 74.4 ± 7.4 years) were recruited. Mean hemoglobin A1c level was 7.5% in patients with DM and 5.7% in the control group (P < 0.0001). A significant reduction in SBN density was noted postoperatively in both DM (P < 0.0001) and non-DM groups (P < 0.0001). Patients with DM had a lower mean SBN density compared with non-DM group, before (P < 0.0001) and after surgery (P < 0.0001). Longer effective phacoemulsification time correlated with a greater decrease in ECD postoperatively in the whole cohort (P < 0.0001), and in the control (P = 0.002) and DM (P = 0.039) groups independently. There was no significant difference in preoperative ECD between the DM group (2254 +/- 426 cells/mm(2)) and non-DM group (2384 +/- 438 cells/mm(2); P = 0.2). [corrected].Subbasal nerve density is reduced after cataract surgery in patients with and without DM. However, lower initial SBN density in patients with DM may predispose them to develop diabetic keratopathy. DM does not predispose to greater endothelial loss following phacoemulsification. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Cornea |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Nerve Fibers |
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dc.subject |
Ophthalmic Nerve |
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dc.subject |
Endothelium, Corneal |
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dc.subject |
Cornea |
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dc.subject |
Epithelium, Corneal |
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dc.subject |
Humans |
en |
dc.subject |
Diabetes Mellitus, Type 2 |
en |
dc.subject |
Hemoglobin A, Glycosylated |
en |
dc.subject |
Microscopy, Confocal |
en |
dc.subject |
Tomography, Optical Coherence |
en |
dc.subject |
Phacoemulsification |
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dc.subject |
Lens Implantation, Intraocular |
en |
dc.subject |
Cell Count |
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dc.subject |
Prospective Studies |
en |
dc.subject |
Aged |
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dc.subject |
Female |
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dc.subject |
Male |
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dc.title |
Corneal microstructural changes in nerve fiber, endothelial and epithelial density after cataract surgery in patients with diabetes mellitus. |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1097/ico.0000000000000320 |
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pubs.issue |
2 |
en |
pubs.begin-page |
177 |
en |
pubs.volume |
34 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
25474233 |
en |
pubs.end-page |
181 |
en |
pubs.publication-status |
Published |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
468662 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
dc.identifier.eissn |
1536-4798 |
en |
pubs.record-created-at-source-date |
2015-01-10 |
en |
pubs.dimensions-id |
25474233 |
en |