Corneal microstructural changes in nerve fiber, endothelial and epithelial density after cataract surgery in patients with diabetes mellitus.

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dc.contributor.author Misra, Stuti en
dc.contributor.author Goh, Yi Wei en
dc.contributor.author Patel, Dipika en
dc.contributor.author Riley, Andrew F en
dc.contributor.author McGhee, Charles en
dc.date.accessioned 2018-10-19T01:54:27Z en
dc.date.issued 2015-02 en
dc.identifier.issn 0277-3740 en
dc.identifier.uri http://hdl.handle.net/2292/42960 en
dc.description.abstract The aim of this study was to analyze microstructural corneal changes following phacoemulsification of cataract with intraocular lens insertion in diabetes mellitus (DM).Prospective study of consecutive patients undergoing phacoemulsification with intraocular lens insertion, over a period of 6 months. Age, gender, serum glycosylated hemoglobin A1c levels, and effective phacoemulsification time were recorded. Anterior segment optical coherence tomography and corneal in vivo confocal microscopy were performed preoperatively and 1-month postoperatively. Subbasal nerve plexus (SBN) density, basal epithelial cell density, and endothelial cell density (ECD) were quantitatively analyzed.Twenty-eight patients with type 2 DM (71.2 ± 7.6 years) and 23 healthy controls (mean age, 74.4 ± 7.4 years) were recruited. Mean hemoglobin A1c level was 7.5% in patients with DM and 5.7% in the control group (P < 0.0001). A significant reduction in SBN density was noted postoperatively in both DM (P < 0.0001) and non-DM groups (P < 0.0001). Patients with DM had a lower mean SBN density compared with non-DM group, before (P < 0.0001) and after surgery (P < 0.0001). Longer effective phacoemulsification time correlated with a greater decrease in ECD postoperatively in the whole cohort (P < 0.0001), and in the control (P = 0.002) and DM (P = 0.039) groups independently. There was no significant difference in preoperative ECD between the DM group (2254 +/- 426 cells/mm(2)) and non-DM group (2384 +/- 438 cells/mm(2); P = 0.2). [corrected].Subbasal nerve density is reduced after cataract surgery in patients with and without DM. However, lower initial SBN density in patients with DM may predispose them to develop diabetic keratopathy. DM does not predispose to greater endothelial loss following phacoemulsification. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Cornea en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Nerve Fibers en
dc.subject Ophthalmic Nerve en
dc.subject Endothelium, Corneal en
dc.subject Cornea en
dc.subject Epithelium, Corneal en
dc.subject Humans en
dc.subject Diabetes Mellitus, Type 2 en
dc.subject Hemoglobin A, Glycosylated en
dc.subject Microscopy, Confocal en
dc.subject Tomography, Optical Coherence en
dc.subject Phacoemulsification en
dc.subject Lens Implantation, Intraocular en
dc.subject Cell Count en
dc.subject Prospective Studies en
dc.subject Aged en
dc.subject Female en
dc.subject Male en
dc.title Corneal microstructural changes in nerve fiber, endothelial and epithelial density after cataract surgery in patients with diabetes mellitus. en
dc.type Journal Article en
dc.identifier.doi 10.1097/ico.0000000000000320 en
pubs.issue 2 en
pubs.begin-page 177 en
pubs.volume 34 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 25474233 en
pubs.end-page 181 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 468662 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Ophthalmology Department en
dc.identifier.eissn 1536-4798 en
pubs.record-created-at-source-date 2015-01-10 en
pubs.dimensions-id 25474233 en


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