Association of prior HPV vaccination with reduced preterm birth: A population based study

Show simple item record Lawton, B en Howe, Anna en Turner, Nicola en Filoche, S en Slatter, T en Devenish, C en Hung, NA en 2018-10-19T02:33:37Z en 2018-01-02 en
dc.identifier.issn 1873-2518 en
dc.identifier.uri en
dc.description.abstract BACKGROUND: Emerging evidence suggests that HPV infection is associated with negative pregnancy outcomes such as preterm birth (PTB), and pre-eclampsia. We aimed to determine if prior HPV vaccination reduced adverse pregnancy outcomes. METHODS: A New Zealand population-based retrospective study linking first pregnancy outcome data (2008-2014 n = 35,646) with prior quadrivalent HPV vaccination status. Primary outcomes were likelihood (odds ratios, ORs) of PTB, pre-eclampsia, and stillbirth. Exposure groups were based on HPV vaccination. Adjusted ORs were calculated for each outcome, controlling for mother's age at delivery, ethnicity, socioeconomic status, health board region at time of delivery, and body mass index and smoking status at time of registration with maternity care provider. RESULTS: Mother's mean age at delivery was 19 (SD 2.1) years. Of 34,994 the pregnancies included in the final study analyses 62.3% of women were unvaccinated, 11.0% vaccinated with one or two doses and 27.7% vaccinated with three doses prior to pregnancy. PTB (OR: 0.87; CI 0.78, 0.96)) was significantly lower for women who previously received the HPV vaccine. A dose response effect was found with each successive dose received decreasing the likelihood of PTB. No associations between the vaccinated and unvaccinated groups were shown for pre-eclampsia or stillbirth. CONCLUSIONS: Prior receipt of the quadrivalent HPV vaccine was associated with a significant reduction in PTB (13%); suggesting that HPV vaccination may be effective in reducing PTB. The potential global public health impact is considerable and there is urgency to undertake further research to replicate and explore these findings. en
dc.publisher Elsevier en
dc.relation.ispartofseries Vaccine en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Association of prior HPV vaccination with reduced preterm birth: A population based study en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.vaccine.2017.11.020 en
pubs.issue 1 en
pubs.begin-page 134 en
pubs.volume 36 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 29174108 en
pubs.end-page 140 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 716042 en Medical and Health Sciences en Population Health en Gen.Practice& Primary Hlthcare en
pubs.record-created-at-source-date 2017-11-20 en
pubs.dimensions-id 29174108 en

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