Neurocognitive Functioning in Depressed Young People: A Systematic Review and Meta-Analysis.

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Show simple item record Goodall, Joanne en Fisher, Caroline en Hetrick, Sarah en Phillips, Lisa en Parrish, Emma M en Allott, Kelly en 2018-10-22T20:32:44Z en 2018-06 en
dc.identifier.issn 1040-7308 en
dc.identifier.uri en
dc.description.abstract BACKGROUND:Depression is among the most common mental health problems for young people. In adults, depression is associated with neurocognitive deficits that reduce the effectiveness of treatment and impair educational and vocational functioning. Compared to adults, less is known about the neurocognitive functioning of young people with depression, and existing research has reported inconsistent findings. METHOD:This systematic review and meta-analysis synthesized the literature on neurocognitive functioning in currently depressed youth aged 12-25 years in comparison to healthy controls. RESULTS:Following a systematic review of the literature, 23 studies were included in the meta-analysis. Poorer performance in the domains of attention (SMD: .50, 95% CI: .18-.83, p = .002), verbal memory (SMD: .78, 95% CI: .50-1.0, p < .001), visual memory (SMD: .65, 95% CI: .30-.99, p < .001), verbal reasoning/knowledge (SMD: .46; 95% CI: .14-.79; p < 0.001) and IQ (SMD: .32; 95% CI: .08-.56; p = 0.01) were identified in depressed youth. Relative weaknesses in processing speed/reaction time and verbal learning were also evident, however, these findings disappeared when the quality of studies was controlled for. Moderator analysis showed a tendency for poorer set-shifting ability in younger depressed participants relative to controls (although non-significant; p = .05). Moderator analysis of medication status showed taking medication was associated with poorer attentional functioning compared to those not taking medication. CONCLUSION:The findings suggest that currently depressed young people display a range of neurocognitive weaknesses which may impact treatment engagement and outcome. The findings support the need to consider neurocognitive functioning when treating youth with depression. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Neuropsychology review en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Humans en
dc.subject Depression en
dc.subject Cognition en
dc.subject Adolescent en
dc.subject Adult en
dc.subject Child en
dc.subject Young Adult en
dc.title Neurocognitive Functioning in Depressed Young People: A Systematic Review and Meta-Analysis. en
dc.type Journal Article en
dc.identifier.doi 10.1007/s11065-018-9373-9 en
pubs.issue 2 en
pubs.begin-page 216 en
pubs.volume 28 en
dc.rights.holder Copyright: The author en
pubs.end-page 231 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Meta-Analysis en
pubs.subtype Systematic Review en
pubs.subtype Journal Article en
pubs.elements-id 739987 en Medical and Health Sciences en School of Medicine en Psychological Medicine Dept en
dc.identifier.eissn 1573-6660 en
pubs.record-created-at-source-date 2018-04-23 en
pubs.dimensions-id 29680959 en

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