Quantifying birefringence in the bovine model of early osteoarthritis using polarisation-sensitive optical coherence tomography and mechanical indentation.

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dc.contributor.author Goodwin, Matthew en
dc.contributor.author Bräuer, Bastian en
dc.contributor.author Lewis, Stephen en
dc.contributor.author Thambyah, Ashvin en
dc.contributor.author Vanholsbeeck, Frederique en
dc.date.accessioned 2018-10-22T21:48:31Z en
dc.date.issued 2018-06-05 en
dc.identifier.citation Scientific reports 8(1):8568 05 Jun 2018 en
dc.identifier.issn 2045-2322 en
dc.identifier.uri http://hdl.handle.net/2292/43083 en
dc.description.abstract Recent studies have shown potential for using polarisation sensitive optical coherence tomography (PS-OCT) to study cartilage morphology, and to be potentially used as an in vivo, non-invasive tool for detecting osteoarthritic changes. However, there has been relatively limited ability of this method to quantify the subtle changes that occur in the early stages of cartilage degeneration. An established mechanical indenting technique that has previously been used to examine the microstructural response of articular cartilage was employed to fix the bovine samples in an indented state. The samples were subject to creep loading with a constant compressive stress of 4.5 MPa and, when imaged using PS-OCT, enabled birefringent banding patterns to be observed. The magnitude of the birefringence was quantified using the birefringence coefficient (BRC) and statistical analysis revealed that PS-OCT is able to detect and quantify significant changes between healthy and early osteoarthritic cartilage (p < 0.001). This presents a novel utilization of PS-OCT for future development as an in vivo assessment tool. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries Scientific reports en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.rights.uri en
dc.subject Cartilage, Articular en
dc.subject Animals en
dc.subject Cattle en
dc.subject Cartilage Diseases en
dc.subject Osteoarthritis en
dc.subject Tomography, Optical Coherence en
dc.subject Algorithms en
dc.subject Stress, Mechanical en
dc.subject Birefringence en
dc.subject Image Processing, Computer-Assisted en
dc.title Quantifying birefringence in the bovine model of early osteoarthritis using polarisation-sensitive optical coherence tomography and mechanical indentation. en
dc.type Journal Article en
dc.identifier.doi 10.1038/s41598-018-25982-9 en
pubs.issue 1 en
pubs.begin-page 8568 en
pubs.volume 8 en
dc.rights.holder Copyright: The authors en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 744297 en
pubs.org-id Engineering en
pubs.org-id Chemical and Materials Eng en
pubs.org-id Science en
pubs.org-id Physics en
pubs.arxiv-id 1709.05129 en
dc.identifier.eissn 2045-2322 en
pubs.record-created-at-source-date 2018-06-07 en
pubs.dimensions-id 29872079 en


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