dc.contributor.author |
Frame, Katie |
en |
dc.contributor.author |
Cheung, Isabella MY |
en |
dc.contributor.author |
Wang, Michael |
en |
dc.contributor.author |
Turnbull, Philip |
en |
dc.contributor.author |
Watters, Grant A |
en |
dc.contributor.author |
Craig, Jennifer |
en |
dc.date.accessioned |
2018-10-22T21:50:22Z |
en |
dc.date.issued |
2018-12 |
en |
dc.identifier.issn |
1367-0484 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43087 |
en |
dc.description.abstract |
PURPOSE:To compare the in vitro antiparasitic effects of MGO™ Manuka honey and tea tree oil against ocular Demodex. METHODS:Fifty-two viable Demodex mites were acquired from the epilated eyelashes of 9 participants with blepharitis and symptomatic dry eye. Viable mites were randomised to one of five treatment groups: cyclodextrin-complexed and uncomplexed Manuka Honey, 100% and 50% tea tree oil, and no treatment. Following treatment application, mite viability was assessed for 240 min, based on limb and body movement and/or the development of a crenated/translucent appearance. Kaplan-Meier survival analysis was then performed. RESULTS:The log-rank test demonstrated a significant treatment effect on the survival distribution of Demodex mites (p < 0.001). Bonferroni-corrected post-hoc pairwise analysis showed that all treatments except for uncomplexed honey effected lower survival probabilities than the untreated group (all p < 0.001). Among the four treatments, survival probabilities were lowest with 100% tea tree oil (all p < 0.001), and highest with uncomplexed honey (all p ≤ 0.001). No difference was observed between complexed honey and 50% tea tree oil (p = 0.81). CONCLUSIONS:The in vitro efficacy of cyclodextrin-complexed Manuka honey was comparable with 50% tea tree oil, an established treatment for ocular Demodex. The findings support future clinical trials investigating the therapeutic effects of complexed honey in demodectic blepharitis patients. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Contact lens & anterior eye : the journal of the British Contact Lens Association |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Eyelashes |
en |
dc.subject |
Animals |
en |
dc.subject |
Humans |
en |
dc.subject |
Mites |
en |
dc.subject |
Eye Infections, Parasitic |
en |
dc.subject |
Blepharitis |
en |
dc.subject |
Magnesium Oxide |
en |
dc.subject |
Tea Tree Oil |
en |
dc.subject |
Anti-Infective Agents, Local |
en |
dc.subject |
Treatment Outcome |
en |
dc.subject |
Administration, Topical |
en |
dc.subject |
Follow-Up Studies |
en |
dc.subject |
Honey |
en |
dc.subject |
Adult |
en |
dc.subject |
Aged |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Young Adult |
en |
dc.title |
Comparing the in vitro effects of MGO™ Manuka honey and tea tree oil on ocular Demodex viability. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.clae.2018.06.006 |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
527 |
en |
pubs.volume |
41 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
530 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
747816 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Optometry and Vision Science |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
dc.identifier.eissn |
1476-5411 |
en |
pubs.record-created-at-source-date |
2018-09-27 |
en |
pubs.dimensions-id |
30253937 |
en |