dc.contributor.author |
Ferguson, L. |
en |
dc.contributor.author |
Han, D. |
en |
dc.contributor.author |
Huebner, Claudia |
en |
dc.contributor.author |
Petermann, I. |
en |
dc.contributor.author |
Barclay, M. |
en |
dc.contributor.author |
Gearry, R. |
en |
dc.contributor.author |
McCulloch, Alan |
en |
dc.contributor.author |
Demmers, Pieter S. |
en |
dc.date.accessioned |
2009-06-12T00:11:12Z |
en |
dc.date.available |
2009-06-12T00:11:12Z |
en |
dc.date.issued |
2009 |
en |
dc.identifier.citation |
Gastroenterology Research and Practice 2009 (591704), 9 pages. 2009 |
en |
dc.identifier.issn |
1687-6121 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/4313 |
en |
dc.description |
An open access copy of this article is available and complies with the copyright holder/publisher conditions. |
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dc.description.abstract |
Inflammatory bowel diseases (IBDs) comprising Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions with polygenic susceptibility. Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammatory response. This study investigates the role that selected single nucleotide polymorphisms (SNPs) and haplotypes in the TNF-alpha receptor (TNSFRSF1B) gene play in the risk of IBD in a New Zealand Caucasian population. DNA samples from 388 CD, 405 UC, 27 indeterminate colitis patients, and 293 randomly selected controls, from Canterbury, New Zealand were screened for 3 common SNPs in TNSFRSF1B: rs1061622 (c.676T>C), rs1061624 (c.∗1663A>G), and rs3397 (c.∗1690T>C), using TaqMan technologies. Carrying the rs1061624 variant decreased the risk of UC in the left colon (OR 0.73, 95% CI=0.54–1.00) and of being a smoker at diagnosis (OR 0.62; 95% CI=0.40–0.96). Carrying the rs3397 variant decreased the risk of penetrating CD (OR 0.62, 95% CI=0.40–0.95). Three marker haplotype analyses revealed highly significant differences between CD patients and control subjects (χ2=29.9, df=7, P=.0001) and UC cases and controls (χ2=46.3, df=7, P<.0001). We conclude that carrying a 3-marker haplotype in the TNSFRSF1B gene may increase (e.g., haplotype of GGC was 2.9-fold more in the CD or UCpatients) or decrease (e.g., TGT was 0.47-fold less in UC patients) the risk of IBD in a New Zealand Caucasian population. |
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dc.publisher |
Hindawi Publishing Corporation |
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dc.relation.ispartofseries |
Gastroenterology Research and Practice |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1687-6121/ |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by/3.0/ |
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dc.title |
Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population |
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dc.type |
Journal Article |
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dc.subject.marsden |
Fields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321006 Gastroenterology and hepatology |
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dc.identifier.doi |
10.1155/2009/591704 |
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pubs.issue |
591704 |
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pubs.begin-page |
9 pages |
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pubs.volume |
2009 |
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dc.description.version |
VoR - Version of Record |
en |
dc.rights.holder |
Copyright: Hindawi Publishing Corporation |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |