Longitudinal Associations of Sleep Duration in Infancy and Early Childhood with Body Composition and Cardiometabolic Health at the Age of 6 Years: The Generation R Study.

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dc.contributor.author Derks, Ivonne PM en
dc.contributor.author Kocevska, Desana en
dc.contributor.author Jaddoe, Vincent WV en
dc.contributor.author Franco, Oscar H en
dc.contributor.author Wake, Melissa en
dc.contributor.author Tiemeier, Henning en
dc.contributor.author Jansen, Pauline W en
dc.date.accessioned 2018-10-23T02:00:46Z en
dc.date.issued 2017-10 en
dc.identifier.issn 2153-2168 en
dc.identifier.uri http://hdl.handle.net/2292/43210 en
dc.description.abstract A short sleep duration is associated with a higher obesity risk from midchildhood onward. However, whether sleep duration in early childhood is associated with body composition and cardiometabolic health remains unclear. This study aims to examine the prospective association of sleep duration in infancy and early childhood with body composition and cardiometabolic health at 6 years of age.Data were available for 5161 children from a population-based cohort in the Netherlands. Sleep duration was assessed at ages 2, 6, 24, and 36 months by parental reports. When children were 6 years old, measures of body composition (iDXA), blood pressure, insulin, and lipid levels were collected. Longitudinal associations among sleep duration, body composition, and cardiometabolic health were studied with multivariable linear regression analyses. In addition, potential bidirectional associations between sleep duration and BMI were studied by using cross-lagged modeling.Shorter sleep duration at 2 months predicted higher BMI and fat mass in 6-year-old children, accounting for confounders and BMI at 2 months (e.g., for BMI, per hour sleep, B = -0.018, 95% CI = -0.026; -0.009). No temporal relationships among sleep duration at other ages, later body composition, and cardiometabolic outcomes were found. The cross-lagged model indicated a bidirectional association between sleep duration and BMI in early life (2 to 6 months of age).Shorter sleep duration at 2 months, but not at later ages, predicted poorer body composition 6 years later. We found no clear evidence for an effect of sleep duration in early life on cardiometabolic health. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Childhood obesity (Print) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Heart en
dc.subject Humans en
dc.subject Birth Weight en
dc.subject Insulin en
dc.subject Lipids en
dc.subject Body Mass Index en
dc.subject Risk Factors en
dc.subject Longitudinal Studies en
dc.subject Prospective Studies en
dc.subject Sleep en
dc.subject Health Status en
dc.subject Body Composition en
dc.subject Metabolism en
dc.subject Blood Pressure en
dc.subject Time Factors en
dc.subject Child en
dc.subject Child, Preschool en
dc.subject Infant en
dc.subject Netherlands en
dc.subject Female en
dc.subject Male en
dc.title Longitudinal Associations of Sleep Duration in Infancy and Early Childhood with Body Composition and Cardiometabolic Health at the Age of 6 Years: The Generation R Study. en
dc.type Journal Article en
dc.identifier.doi 10.1089/chi.2016.0341 en
pubs.issue 5 en
pubs.begin-page 400 en
pubs.volume 13 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 28604071 en
pubs.end-page 408 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 630313 en
dc.identifier.eissn 2153-2176 en
pubs.record-created-at-source-date 2017-06-13 en
pubs.dimensions-id 28604071 en


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