dc.contributor.author |
Gilbert, Kathleen |
en |
dc.contributor.author |
Forsch, Nickolas |
en |
dc.contributor.author |
Hegde, Sanjeet |
en |
dc.contributor.author |
Mauger, Charlene |
en |
dc.contributor.author |
Omens, Jeffrey H |
en |
dc.contributor.author |
Perry, James C |
en |
dc.contributor.author |
Pontré, Beau |
en |
dc.contributor.author |
Suinesiaputra, Avan |
en |
dc.contributor.author |
Young, Alistair |
en |
dc.contributor.author |
McCulloch, Andrew D |
en |
dc.date.accessioned |
2018-10-24T01:10:03Z |
en |
dc.date.issued |
2018-04 |
en |
dc.identifier.issn |
1937-5387 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43379 |
en |
dc.description.abstract |
Approximately 1% of all babies are born with some form of congenital heart defect. Many serious forms of CHD can now be surgically corrected after birth, which has led to improved survival into adulthood. However, many patients require serial monitoring to evaluate progression of heart failure and determine timing of interventions. Accurate multidimensional quantification of regional heart shape and function is required for characterizing these patients. A computational atlas of single ventricle and biventricular heart shape and function enables quantification of remodeling in terms of z scores in relation to specific reference populations. Progression of disease can then be monitored effectively by longitudinal evaluation of z scores. A biomechanical analysis of cardiac function in relation to population variation enables investigation of the underlying mechanisms for developing pathology. Here, we summarize recent progress in this field, with examples in single ventricle and biventricular congenital pathologies. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Journal of cardiovascular translational research |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Heart Defects, Congenital |
en |
dc.subject |
Disease Progression |
en |
dc.subject |
Prognosis |
en |
dc.subject |
Ventricular Function |
en |
dc.subject |
Ventricular Remodeling |
en |
dc.subject |
Models, Cardiovascular |
en |
dc.subject |
Patient Selection |
en |
dc.subject |
Time Factors |
en |
dc.subject |
Patient-Centered Care |
en |
dc.subject |
Atlases as Topic |
en |
dc.subject |
Patient-Specific Modeling |
en |
dc.subject |
Clinical Decision-Making |
en |
dc.title |
Atlas-Based Computational Analysis of Heart Shape and Function in Congenital Heart Disease. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s12265-017-9778-5 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
123 |
en |
pubs.volume |
11 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
29294215 |
en |
pubs.end-page |
132 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.subtype |
Research Support, N.I.H., Extramural |
en |
pubs.elements-id |
720368 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
dc.identifier.eissn |
1937-5395 |
en |
pubs.record-created-at-source-date |
2018-01-03 |
en |
pubs.dimensions-id |
29294215 |
en |