Quantitative electroencephalographic patterns in normal preterm infants over the first week after birth

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dc.contributor.author West, Claire en
dc.contributor.author Harding, Jane en
dc.contributor.author Williams, Christopher en
dc.contributor.author Gunning, Mark en
dc.contributor.author Battin, Malcolm en
dc.date.accessioned 2018-10-25T02:56:28Z en
dc.date.issued 2006-01 en
dc.identifier.issn 0378-3782 en
dc.identifier.uri http://hdl.handle.net/2292/43464 en
dc.description.abstract Background: Currently available tools to assist clinicians with prediction of neurodevelopmental outcome of preterm infants are inadequate. Modified cotside electroencephalography (EEG) has the ability to produce quantitative electrophysiologic measures. These measures may be useful in future prediction of outcome. Aim: To determine patterns of change in quantitative EEG measures in preterm infants during their first week after birth. Design: Observational. Subjects: Preterm infants born at less than 32 weeks completed gestation surviving to discharge with unremarkable serial ultrasound scans. Outcome measures: Changes in continuity, amplitude and spectral edge frequency measures of EEGs obtained over the first week after birth. Results: Results of EEGs performed using a novel EEG device on 63 infants are reported here. Their median (range) gestation was 29 (24–31) weeks and birthweight was 1235 (540–1980) g. Quantitative measures of EEG continuity increased over the first week after birth from 72 (25–99)% to 92 (54–100)% at the 25 μV threshold, and from 39 (10–87)% to 64 (34–75)% at the 50 μV threshold, both p<0.0001. There was a related 32% increase in median amplitude from 5.8 (2.6–10.6) μV on day 1 to 7.6 (4.3–9.4) μV on day 4, p=0.005. There was a trend for average spectral edge frequency to fall from 10.7 (9.3–12.9) Hz on day 1 to 9.9 (8.1–12.3) Hz on day 3, p=0.06. Each gestational tertile showed similar patterns. Conclusions: There are consistent changes in quantitative neurophysiologic measures over the first week after birth, and particularly measures of continuity over the first 4 days, in normal preterm infants. en
dc.relation.ispartofseries Early Human Development en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Quantitative electroencephalographic patterns in normal preterm infants over the first week after birth en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.earlhumdev.2005.07.009 en
pubs.issue 1 en
pubs.begin-page 43 en
pubs.volume 82 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 16169163 en
pubs.author-url http://www.earlyhumandevelopment.com/article/S0378-3782(05)00157-X/abstract en
pubs.end-page 51 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 44770 en
pubs.org-id Liggins Institute en
pubs.org-id LiFePATH en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Physiology Division en
dc.identifier.eissn 1872-6232 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 16169163 en

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