dc.contributor.author |
Zhernakova, Alexandra |
en |
dc.contributor.author |
Kurilshikov, Alexander |
en |
dc.contributor.author |
Bonder, Marc Jan |
en |
dc.contributor.author |
Tigchelaar, Ettje F |
en |
dc.contributor.author |
Schirmer, Melanie |
en |
dc.contributor.author |
Vatanen, Tommi |
en |
dc.contributor.author |
Mujagic, Zlatan |
en |
dc.contributor.author |
Vila, Arnau Vich |
en |
dc.contributor.author |
Falony, Gwen |
en |
dc.contributor.author |
Vieira-Silva, Sara |
en |
dc.contributor.author |
Wang, Jun |
en |
dc.contributor.author |
Imhann, Floris |
en |
dc.contributor.author |
Brandsma, Eelke |
en |
dc.contributor.author |
Jankipersadsing, Soesma A |
en |
dc.contributor.author |
Joossens, Marie |
en |
dc.contributor.author |
Cenit, Maria Carmen |
en |
dc.contributor.author |
Deelen, Patrick |
en |
dc.contributor.author |
Swertz, Morris A |
en |
dc.contributor.author |
LifeLines cohort study |
en |
dc.contributor.author |
Weersma, Rinse K |
en |
dc.contributor.author |
Feskens, Edith JM |
en |
dc.contributor.author |
Netea, Mihai G |
en |
dc.contributor.author |
Gevers, Dirk |
en |
dc.contributor.author |
Jonkers, Daisy |
en |
dc.contributor.author |
Franke, Lude |
en |
dc.contributor.author |
Aulchenko, Yurii S |
en |
dc.contributor.author |
Huttenhower, Curtis |
en |
dc.contributor.author |
Raes, Jeroen |
en |
dc.contributor.author |
Hofker, Marten H |
en |
dc.contributor.author |
Xavier, Ramnik J |
en |
dc.contributor.author |
Wijmenga, Cisca |
en |
dc.contributor.author |
Fu, Jingyuan |
en |
dc.date.accessioned |
2018-10-26T02:24:11Z |
en |
dc.date.issued |
2016-04-28 |
en |
dc.identifier.issn |
0036-8075 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43518 |
en |
dc.description.abstract |
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Science (New York, N.Y.) |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
LifeLines cohort study |
en |
dc.subject |
Gastrointestinal Tract |
en |
dc.subject |
Feces |
en |
dc.subject |
Humans |
en |
dc.subject |
Bacteria |
en |
dc.subject |
RNA, Ribosomal, 16S |
en |
dc.subject |
Genetic Markers |
en |
dc.subject |
Diet |
en |
dc.subject |
Phylogeny |
en |
dc.subject |
Netherlands |
en |
dc.subject |
Enteroendocrine Cells |
en |
dc.subject |
Chromogranin A |
en |
dc.subject |
Metagenomics |
en |
dc.subject |
High-Throughput Nucleotide Sequencing |
en |
dc.subject |
Gastrointestinal Microbiome |
en |
dc.title |
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1126/science.aad3369 |
en |
pubs.issue |
6285 |
en |
pubs.begin-page |
565 |
en |
pubs.volume |
352 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
27126040 |
en |
pubs.end-page |
569 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
734580 |
en |
pubs.org-id |
Liggins Institute |
en |
dc.identifier.eissn |
1095-9203 |
en |
pubs.record-created-at-source-date |
2016-04-30 |
en |
pubs.dimensions-id |
27126040 |
en |