dc.contributor.author |
Vieira, Matias C |
en |
dc.contributor.author |
McCowan, Lesley |
en |
dc.contributor.author |
North, Robyn A |
en |
dc.contributor.author |
Myers, Jenny E |
en |
dc.contributor.author |
Walker, James J |
en |
dc.contributor.author |
Baker, Philip |
en |
dc.contributor.author |
Dekker, Gustaaf A |
en |
dc.contributor.author |
Kenny, Louise C |
en |
dc.contributor.author |
Poston, Lucilla |
en |
dc.contributor.author |
Pasupathy, Dharmintra |
en |
dc.contributor.author |
SCOPE consortium |
en |
dc.date.accessioned |
2018-10-26T02:53:44Z |
en |
dc.date.issued |
2018-05-12 |
en |
dc.identifier.citation |
Acta obstetricia et gynecologica Scandinavica 97(8):1015-1024, Aug 2018 |
en |
dc.identifier.issn |
0001-6349 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43547 |
en |
dc.description.abstract |
Large-for-gestational-age infants are associated with increased risk of neonatal morbidity and mortality. However, most of them will not have adverse outcomes. Our aim was to identify antenatal clinical factors associated with neonatal morbidity in large-for-gestational-age infants.Nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study were included. We compared maternal and fetal factors between large-for-gestational-age infants (birthweight >90th customized centile) with and without neonatal morbidity, defined as admission to a neonatal intensive care unit or severe neonatal morbidity. Factors were selected based on a priori hypotheses of association and included maternal demography, anthropometric measures and self-reported physical activity (15 and 20 weeks), fetal biometry (20 weeks), and clinical information. Multivariable logistic regression was used to identify risk factors. Stratified analyses were performed by maternal obesity and physical activity.Among term pregnancies, prevalence of large-for-gestational-age infants was 9.3% (491/5255), with 11.8% (58/491) prevalence of neonatal morbidity. Random glucose at 20 weeks (odds ratio 1.52; 95% confidence interval 1.17-1.97, per 1 mmol/L increase) and no regular physical activity at 20 weeks (odds ratio 3.93; 95% confidence interval 1.75-8.83) were associated with increased risk of neonatal morbidity after adjustment for birthweight, gestational age at delivery and gestational diabetes. The increased risk associated with higher glucose levels was not evident in women with regular physical activity or without obesity.Regular physical activity in mid-pregnancy is associated with lower risk for neonatal morbidity in large-for-gestational-age infants and seems to offer protection against the increased risk associated with higher maternal glucose levels. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Acta obstetricia et gynecologica Scandinavica |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights |
This is the peer reviewed version which has been published in final form at http://dx.doi.org/10.1111/aogs.13362. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html |
en |
dc.subject |
SCOPE consortium |
en |
dc.title |
Antenatal risk factors associated with neonatal morbidity in large-for-gestational-age infants: an international prospective cohort study. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/aogs.13362 |
en |
dc.rights.holder |
Copyright: Nordic Federation of Societies of Obstetrics and Gynecology |
en |
dc.identifier.pmid |
29753307 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
740294 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
dc.identifier.eissn |
1600-0412 |
en |
pubs.record-created-at-source-date |
2018-05-13 |
en |
pubs.dimensions-id |
29753307 |
en |