dc.contributor.author |
Guan, Jian |
en |
dc.contributor.author |
Singh-Mallah, G |
en |
dc.contributor.author |
Liu, K |
en |
dc.contributor.author |
Thorstensen, Eric |
en |
dc.contributor.author |
Shorten, P |
en |
dc.contributor.author |
Mitchell, Edwin |
en |
dc.contributor.author |
Taylor, Rennae |
en |
dc.contributor.author |
Harris, Paul |
en |
dc.contributor.author |
Brimble, Margaret |
en |
dc.contributor.author |
Thompson, John |
en |
dc.contributor.author |
Murphy, Rinki |
en |
dc.date.accessioned |
2018-10-26T03:24:23Z |
en |
dc.date.issued |
2018-05 |
en |
dc.identifier.issn |
0393-974X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43579 |
en |
dc.description.abstract |
Cyclic Glycine-Proline (cGP) regulates the homeostasis of insulin-like growth factor (IGF)-1 function and cGP/IGF-1 ratio determines IGF-1 bioactivity in vitro and in vivo. Plasma IGF-1 represents largely inactive IGF-1 and weakly associated with human obesity and hypertension. We evaluated the regulatory role for cGP in pregnancy-related obesity and hypertension, and in obesity status between pregnancy and postpartum. Women were recruited in their first pregnancy. A cross-sectional study compared plasma concentration of cGP, IGF-1 and IGF binding protein (IGFBP)-3 in women with obesity and/or hypertension to normal controls 6-year postpartum using UPLC-MS and ELISA. A longitudinal study compared the changes of these peptides from 15-week gestation to 6-year post-partum in the women who remained normal weight, remained obese or changed to obese or to normal respectively. Study 1 is a cross-sectional study. The obese group had lower IGF-1(p = 0.001), higher cGP/IGF-1 ratio (p = 0.0055) and the hypertensive group had lower IGFBP-3 (p = 0.046) and cGP (p = 0.043) than the controls. Study 2 is a longitudinal study. Women with weight loss had increased cGP/IGF-1 ratio (p = 0.0026) and decreased IGFBP-3 (p = 0.0001) compared with women whose weight remained normal. Women with weight gain had lower IGFBP-3 (p less than 0.0001) only. Women who remained obese had increased cGP/IGF-1 ratio (p = 0.006) only. Increase in cGP/IGF-1 ratio is associated with obesity, but not hypertension. Changes of IGFBP-3 and/or cGP/IGF-1 ratio are associated with weight changes. The data suggest the role for cGP in obesity through autocrine regulation of IGF-1. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Journal of biological regulators and homeostatic agents |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Pregnancy Complications |
en |
dc.subject |
Obesity |
en |
dc.subject |
Peptides, Cyclic |
en |
dc.subject |
Insulin-Like Growth Factor I |
en |
dc.subject |
Insulin-Like Growth Factor Binding Protein 3 |
en |
dc.subject |
Follow-Up Studies |
en |
dc.subject |
Cross-Sectional Studies |
en |
dc.subject |
Pregnancy |
en |
dc.subject |
Adult |
en |
dc.subject |
Female |
en |
dc.title |
The role for cyclic Glycine-Proline, a biological regulator of insulin-like growth factor-1 in pregnancy-related obesity and weight changes. |
en |
dc.type |
Journal Article |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
465 |
en |
pubs.volume |
32 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
478 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
746929 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
pubs.org-id |
Paediatrics Child & Youth Hlth |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1724-6083 |
en |
pubs.record-created-at-source-date |
2018-06-21 |
en |
pubs.dimensions-id |
29921371 |
en |