dc.contributor.author |
Jacobson, Elsie |
en |
dc.contributor.author |
Perry, Johanna |
en |
dc.contributor.author |
Long, David |
en |
dc.contributor.author |
Vickers, Mark |
en |
dc.contributor.author |
O'Sullivan, Justin |
en |
dc.date.accessioned |
2018-11-01T21:15:19Z |
en |
dc.date.issued |
2016-09-27 |
en |
dc.identifier.issn |
1949-1034 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43754 |
en |
dc.description.abstract |
Immune cells react to a wide range of environments, both chemical and physical. While the former has been extensively studied, there is growing evidence that physical and in particular mechanical forces also affect immune cell behavior and development. In order to elicit a response that affects immune cell behavior or development, environmental signals must often reach the nucleus. Chemical and mechanical signals can initiate signal transduction pathways, but mechanical forces may also have a more direct route to the nucleus, altering nuclear shape via mechanotransduction. The three-dimensional organization of DNA allows for the possibility that altering nuclear shape directly remodels chromatin, redistributing critical regulatory elements and proteins, and resulting in wide-scale gene expression changes. As such, integrating mechanotransduction and genome architecture into the immunology toolkit will improve our understanding of immune development and disease. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Nucleus (Austin, Tex.) |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Animals |
en |
dc.subject |
Humans |
en |
dc.subject |
Mechanotransduction, Cellular |
en |
dc.subject |
Cell Differentiation |
en |
dc.subject |
Cell Shape |
en |
dc.subject |
Immunity |
en |
dc.subject |
Genome |
en |
dc.subject |
Transendothelial and Transepithelial Migration |
en |
dc.title |
A potential role for genome structure in the translation of mechanical force during immune cell development. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1080/19491034.2016.1238998 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
462 |
en |
pubs.volume |
7 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
27673560 |
en |
pubs.end-page |
475 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
review-article |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
542073 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1949-1042 |
en |
pubs.record-created-at-source-date |
2016-09-27 |
en |
pubs.dimensions-id |
27673560 |
en |