dc.contributor.author |
Doynova, MD |
en |
dc.contributor.author |
Berretta, A |
en |
dc.contributor.author |
Jones, Mary Beatrix |
en |
dc.contributor.author |
Jasoni, CL |
en |
dc.contributor.author |
Vickers, Mark |
en |
dc.contributor.author |
O'Sullivan, Justin |
en |
dc.date.accessioned |
2018-11-01T21:16:21Z |
en |
dc.date.issued |
2016-09 |
en |
dc.identifier.issn |
1567-7249 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43755 |
en |
dc.description.abstract |
Chromosome Conformation Capture techniques regularly detect physical interactions between mitochondrial and nuclear DNA (i.e. mito-nDNA interactions) in mammalian cells. We have evaluated mito-nDNA interactions captured by HiC and Circular Chromosome Conformation Capture (4C). We show that these mito-nDNA interactions are statistically significant and shared between biological and technical replicates. The most frequent interactions occur with repetitive DNA sequences, including centromeres in human cell lines and the 18S rDNA in mouse cortical astrocytes. Our results demonstrate a degree of selective regulation in the identity of the interacting mitochondrial partners confirming that mito-nDNA interactions in mammalian cells are not random. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Mitochondrion |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Cell Nucleus |
en |
dc.subject |
Mitochondria |
en |
dc.subject |
Animals |
en |
dc.subject |
Humans |
en |
dc.subject |
Mice |
en |
dc.subject |
DNA |
en |
dc.title |
Interactions between mitochondrial and nuclear DNA in mammalian cells are non-random. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.mito.2016.08.003 |
en |
pubs.begin-page |
187 |
en |
pubs.volume |
30 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
27503698 |
en |
pubs.end-page |
196 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
539997 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Statistics |
en |
dc.identifier.eissn |
1872-8278 |
en |
pubs.record-created-at-source-date |
2016-09-14 |
en |
pubs.dimensions-id |
27503698 |
en |