dc.contributor.author |
Hall, Christopher |
en |
dc.contributor.author |
Boyle, RH |
en |
dc.contributor.author |
Astin, Jonathan |
en |
dc.contributor.author |
Flores, MV |
en |
dc.contributor.author |
Oehlers, SH |
en |
dc.contributor.author |
Sanderson, Leslie |
en |
dc.contributor.author |
Ellett, F |
en |
dc.contributor.author |
Lieschke, GJ |
en |
dc.contributor.author |
Crosier, Kathryn |
en |
dc.contributor.author |
Crosier, Philip |
en |
dc.date.accessioned |
2018-11-01T22:41:21Z |
en |
dc.date.issued |
2013-08-06 |
en |
dc.identifier.issn |
1550-4131 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43782 |
en |
dc.description.abstract |
Evidence suggests the bactericidal activity of mitochondria-derived reactive oxygen species (mROS) directly contributes to killing phagocytozed bacteria. Infection-responsive components that regulate this process remain incompletely understood. We describe a role for the mitochondria-localizing enzyme encoded by Immunoresponsive gene 1 (IRG1) during the utilization of fatty acids as a fuel for oxidative phosphorylation (OXPHOS) and associated mROS production. In a zebrafish infection model, infection-responsive expression of zebrafish irg1 is specific to macrophage-lineage cells and is regulated cooperatively by glucocorticoid and JAK/STAT signaling pathways. Irg1-depleted macrophage-lineage cells are impaired in their ability to utilize fatty acids as an energy substrate for OXPHOS-derived mROS production resulting in defective bactericidal activity. Additionally, the requirement for fatty acid β-oxidation during infection-responsive mROS production and bactericidal activity toward intracellular bacteria is conserved in murine macrophages. These results reveal IRG1 as a key component of the immunometabolism axis, connecting infection, cellular metabolism, and macrophage effector function. |
en |
dc.description.uri |
http://www.ncbi.nlm.nih.gov/pubmed/23931757 |
en |
dc.relation.ispartofseries |
Cell Metabolism |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.cmet.2013.06.018 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
265 |
en |
pubs.volume |
18 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
23931757 |
en |
pubs.author-url |
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00288-X |
en |
pubs.end-page |
278 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
369375 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1932-7420 |
en |
pubs.record-created-at-source-date |
2012-12-11 |
en |
pubs.dimensions-id |
23931757 |
en |