dc.contributor.author |
Solanki, KK |
en |
dc.contributor.author |
Hor, C |
en |
dc.contributor.author |
Chang, WSJ |
en |
dc.contributor.author |
Frampton, C |
en |
dc.contributor.author |
White, Douglas |
en |
dc.date.accessioned |
2018-11-04T23:40:16Z |
en |
dc.date.issued |
2017 |
en |
dc.identifier.issn |
1756-185X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43831 |
en |
dc.description.abstract |
Aim: Cutaneous involvement is an early manifestation of systemic sclerosis (SSc). Localized areas of ‘salt and pepper skin’ (S&P) may develop. We hypothesize that S&P skin occurs frequently in diffuse cutaneous (dc) SSc which can be used in its early diagnosis and may correlate with joint contractures. Methods: Sixty-five patients were recruited for this study. The demographic profiles of SSc were ascertained from hospital records. These patients fulfilled the 2013 American College of Rheumatology/European League Against Rheumatism classification criteria. Patients were examined for skin pigmentary changes, modified Rodnan skin score (mRSS), telengiectasias, calcinosis, arthritis and joint contractures and pruritus. Results: Sixty-five patients (59 female) were recruited with median age of 62.87 years. Forty-four had limited cutaneous SSc, 16 dcSSc, five had scleroderma overlap syndrome. Multivariate stepwise logistic regression indicated that mRSS severity and the presence of contractures were independently (P < 0.05) associated with dcSSc. The strong positive association between S&P and mRSS severity may explain the non-significance of S&P in this analysis. If mRSS severity is not included in the logistic regression analysis, the presence of contractures and S&P (odds ratio = 15.1) show significant (P < 0.01) independent associations with the dcSSc subtype. S&P skin and pruritus were similar in patients with Scl-70 and anti-RNA polymerase antibodies. Anti-centromere antibodies were negatively associated with S&P (χ2 = 7.89, P = 0.005). Conclusion: Our study demonstrates strong association of S&P skin with dcSSc (69%), increased risk of pruritus and contractures. Its presence can be used as another clinical tool to diagnose dcSSc in early stages. Observing for S&P skin changes does not require much training. |
en |
dc.relation.ispartofseries |
Int J Rheum Dis |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
calcinosis |
en |
dc.subject |
clinical aspects systemic sclerosis |
en |
dc.subject |
joint contractures |
en |
dc.subject |
pruritus |
en |
dc.subject |
salt and pepper skin |
en |
dc.title |
Clinical utility of hypo- and hyperpigmentation of skin in diffuse cutaneous systemic sclerosis |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/1756-185X.13049 |
en |
pubs.begin-page |
n/a |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
28261995 |
en |
pubs.author-url |
http://dx.doi.org/10.1111/1756-185X.13049 |
en |
pubs.end-page |
n/a |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
JOUR |
en |
pubs.elements-id |
616195 |
en |
pubs.record-created-at-source-date |
2017-03-07 |
en |
pubs.dimensions-id |
28261995 |
en |