The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.

Show simple item record Kostic, Aleksandar D en Gevers, Dirk en Siljander, Heli en Vatanen, Tommi en Hyötyläinen, Tuulia en Hämäläinen, Anu-Maaria en Peet, Aleksandr en Tillmann, Vallo en Pöhö, Päivi en Mattila, Ismo en Lähdesmäki, Harri en Franzosa, Eric A en Vaarala, Outi en de Goffau, Marcus en Harmsen, Hermie en Ilonen, Jorma en Virtanen, Suvi M en Clish, Clary B en Orešič, Matej en Huttenhower, Curtis en Knip, Mikael en DIABIMMUNE Study Group en Xavier, Ramnik J en 2018-11-05T01:40:19Z en 2015-02-05 en
dc.identifier.issn 1934-6069 en
dc.identifier.uri en
dc.description.abstract Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1 diabetes (T1D), we examined a cohort of 33 infants genetically predisposed to T1D. Modeling trajectories of microbial abundances through infancy revealed a subset of microbial relationships shared across most subjects. Although strain composition of a given species was highly variable between individuals, it was stable within individuals throughout infancy. Metabolic composition and metabolic pathway abundance remained constant across time. A marked drop in alpha-diversity was observed in T1D progressors in the time window between seroconversion and T1D diagnosis, accompanied by spikes in inflammation-favoring organisms, gene functions, and serum and stool metabolites. This work identifies trends in the development of the human infant gut microbiome along with specific alterations that precede T1D onset and distinguish T1D progressors from nonprogressors. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Cell host & microbe en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject DIABIMMUNE Study Group en
dc.subject Gastrointestinal Tract en
dc.subject Humans en
dc.subject Diabetes Mellitus, Type 1 en
dc.subject Cohort Studies en
dc.subject Infant en
dc.subject Gastrointestinal Microbiome en
dc.title The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.chom.2015.01.001 en
pubs.issue 2 en
pubs.begin-page 260 en
pubs.volume 17 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 25662751 en
pubs.end-page 273 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.subtype Research Support, N.I.H., Extramural en
pubs.elements-id 734581 en Liggins Institute en
dc.identifier.eissn 1934-6069 en
pubs.record-created-at-source-date 2015-02-14 en
pubs.dimensions-id 25662751 en

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