TFOS DEWS II Definition and Classification Report.

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dc.contributor.author Craig, Jennifer en
dc.contributor.author Nichols, Kelly K en
dc.contributor.author Akpek, Esen K en
dc.contributor.author Caffery, Barbara en
dc.contributor.author Dua, Harminder S en
dc.contributor.author Joo, Choun-Ki en
dc.contributor.author Liu, Zuguo en
dc.contributor.author Nelson, J Daniel en
dc.contributor.author Nichols, Jason J en
dc.contributor.author Tsubota, Kazuo en
dc.contributor.author Stapleton, Fiona en
dc.date.accessioned 2018-11-05T22:42:40Z en
dc.date.issued 2017-07-20 en
dc.identifier.issn 1542-0124 en
dc.identifier.uri http://hdl.handle.net/2292/43953 en
dc.description.abstract The goals of the TFOS DEWS II Definition and Classification Subcommittee were to create an evidence-based definition and a contemporary classification system for dry eye disease (DED). The new definition recognizes the multifactorial nature of dry eye as a disease where loss of homeostasis of the tear film is the central pathophysiological concept. Ocular symptoms, as a broader term that encompasses reports of discomfort or visual disturbance, feature in the definition and the key etiologies of tear film instability, hyperosmolarity, and ocular surface inflammation and damage were determined to be important for inclusion in the definition. In the light of new data, neurosensory abnormalities were also included in the definition for the first time. In the classification of DED, recent evidence supports a scheme based on the pathophysiology where aqueous deficient and evaporative dry eye exist as a continuum, such that elements of each are considered in diagnosis and management. Central to the scheme is a positive diagnosis of DED with signs and symptoms, and this is directed towards management to restore homeostasis. The scheme also allows consideration of various related manifestations, such as non-obvious disease involving ocular surface signs without related symptoms, including neurotrophic conditions where dysfunctional sensation exists, and cases where symptoms exist without demonstrable ocular surface signs, including neuropathic pain. This approach is not intended to override clinical assessment and judgment but should prove helpful in guiding clinical management and research. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries The ocular surface en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Eye en
dc.subject Tears en
dc.subject Humans en
dc.subject Keratoconjunctivitis Sicca en
dc.subject Dry Eye Syndromes en
dc.title TFOS DEWS II Definition and Classification Report. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jtos.2017.05.008 en
pubs.issue 3 en
pubs.begin-page 276 en
pubs.volume 15 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 28736335 en
pubs.end-page 283 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 644686 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Ophthalmology Department en
dc.identifier.eissn 1937-5913 en
pubs.record-created-at-source-date 2017-07-25 en
pubs.dimensions-id 28736335 en


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