The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study.

Show simple item record Boyle, VT en Thorstensen, Eric en Thompson, John en McCowan, Lesley en Mitchell, Edwin en Godfrey, KM en Poston, L en Wall, Clare en Murphy, Rinki en Cutfield, Wayne en Kenealy, Timothy en Kenny, LC en Baker, Philip en 2018-11-05T22:42:48Z en 2017-12 en
dc.identifier.citation International journal of obesity 41(12):1755-1760 Dec 2017 en
dc.identifier.issn 0307-0565 en
dc.identifier.uri en
dc.description.abstract Vitamin D insufficiency (defined as <75 nmol l-1) is widespread among pregnant women around the world and has been proposed to influence offspring outcomes in childhood and into adult life, including adiposity and allergy. Disorders, including asthma and eczema, are on the rise among children. Our aim was to investigate the relationship between maternal 25-hydroxyvitamin D status in pregnancy and offspring adiposity, asthma and eczema in childhood.Maternal 25-hydroxyvitamin D concentrations were analysed in serum samples collected at 15 weeks' gestation from 1710 participants of the prospective Screening for Pregnancy Endpoints cohort study. The offspring of 1208 mothers were followed up at age 5-6 years. Data collected included height, weight, percentage body fat (PBF, measured by bioimpedance) and history of asthma and eczema. Multivariable analysis controlled for maternal body mass index (BMI), age and sex of the child and season of serum sampling.Complete data were available for 922 mother-child pairs. Each 10 nmol l-1 increase in maternal 25-hydroxyvitamin D concentration at 15 weeks' gestation was associated with a decrease in offspring PBF of 0.2% (95% confidence interval 0.04-0.36%, P=0.01) after adjustment for confounders but was not related to child BMI z-score. Maternal mean (±s.d.) 25-hydroxyvitamin D concentration was similar in children who did and did not have asthma (71.7±26.1 vs 73.3±27.1 nmol l-1, P=0.5), severe asthma (68.6±28.6 vs 73.3±26.8 nmol l-1, P=0.2) and eczema (71.9±27.0 vs 73.2±27.0 nmol l-1, P=0.5).The finding of a relationship between maternal vitamin D status and adiposity in childhood is important, particularly because vitamin D insufficiency in pregnancy is highly prevalent. The association between maternal vitamin D supplementation in pregnancy and adiposity in the offspring merits examination in randomised controlled trials. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries International journal of obesity (2005) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Humans en
dc.subject Asthma en
dc.subject Eczema en
dc.subject Vitamin D Deficiency en
dc.subject Vitamin D en
dc.subject Nutrition Surveys en
dc.subject Follow-Up Studies en
dc.subject Prospective Studies en
dc.subject Mothers en
dc.subject Pregnancy en
dc.subject Adult en
dc.subject Child, Preschool en
dc.subject Infant en
dc.subject Infant, Newborn en
dc.subject Sweden en
dc.subject Female en
dc.subject Male en
dc.subject Adiposity en
dc.subject Maternal Nutritional Physiological Phenomena en
dc.subject Pediatric Obesity en
dc.subject Surveys and Questionnaires en
dc.title The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study. en
dc.type Journal Article en
dc.identifier.doi 10.1038/ijo.2017.182 en
pubs.issue 12 en
pubs.begin-page 1755 en
pubs.volume 41 en
dc.rights.holder Copyright: Macmillan Publishers Limited, part of Springer Nature en
dc.identifier.pmid 28775375 en
pubs.end-page 1760 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.subtype Observational Study en
pubs.elements-id 645041 en Liggins Institute en Medical and Health Sciences en Medical Sciences en Nutrition en School of Medicine en Medicine Department en Obstetrics and Gynaecology en Paediatrics Child & Youth Hlth en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1476-5497 en
pubs.record-created-at-source-date 2017-08-05 en
pubs.dimensions-id 28775375 en

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