Dose-dependent effects of folic acid on plasma homocysteine in a randomized trial conducted among 723 individuals with coronary heart disease

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dc.contributor.author Dudman, N en
dc.contributor.author Hunt, D en
dc.contributor.author MacMahon, S en
dc.contributor.author Neal, B en
dc.contributor.author Richards, M en
dc.contributor.author Simes, J en
dc.contributor.author Tonkin, A en
dc.contributor.author Wilcken, D en
dc.contributor.author Murphy, J en
dc.contributor.author Cleverly, Y en
dc.date.accessioned 2018-11-05T22:44:23Z en
dc.date.issued 2002 en
dc.identifier.citation European Heart Journal, 2002, 23 pp. 1509 - 1515 (7) en
dc.identifier.issn 0195-668X en
dc.identifier.uri http://hdl.handle.net/2292/43956 en
dc.description.abstract Aims To determine the effects on homocysteine levels of two doses of folic acid compared to placebo, where the high dose is typical of that provided by pharmacological intervention and the low dose approximates that provided by dietary supplementation. Methods and Results The PACIFIC study was a doubleblind, placebo-controlled, factorial randomized trial. Seven hundred and twenty-three individuals with a history of myocardial infarction or unstable angina were recruited from 28 clinical cardiology centres in Australia and New Zealand and randomized to folic acid 2·0 mg daily, folic acid 0·2 mg daily or placebo. The primary outcome, homocysteine, was measured using a fluorescence polarization immunoassay. Compared to placebo, 2·0mg folic acid reduced homocysteine by 1·8 mol . l 1 [95% confidence interval (CI) 1·3– 2·3] and 0·2 mg reduced homocysteine by 1·2 mol . l 1 (95% CI 0·8–1·7). The higher dose reduced homocysteine significantly more than the lower dose (P=0·01). Conclusions Both doses of folic acid reduced homocysteine, but the effects of the 2·0 mg dose were about one third greater than the 0·2 mg dose. Fortification of foods with folic acid should result in population-wide lower levels of homocysteine but high-dose pharmacological supplementation would produce greater reductions for high-risk individuals. en
dc.publisher Oxford University Press (OUP) en
dc.relation.ispartofseries European Heart Journal en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Dose-dependent effects of folic acid on plasma homocysteine in a randomized trial conducted among 723 individuals with coronary heart disease en
dc.type Journal Article en
dc.identifier.doi 10.1053/euhj.2002.3161 en
pubs.issue 19 en
pubs.begin-page 1509 en
pubs.volume 23 en
dc.identifier.pmid 12395803 en
pubs.author-url http://eurheartj.oxfordjournals.org/content/ehj/23/19/1509.full.pdf en
pubs.end-page 1515 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 32902 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
dc.identifier.eissn 1522-9645 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 12395803 en


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