dc.contributor.author |
Dudman, N |
en |
dc.contributor.author |
Hunt, D |
en |
dc.contributor.author |
MacMahon, S |
en |
dc.contributor.author |
Neal, B |
en |
dc.contributor.author |
Richards, M |
en |
dc.contributor.author |
Simes, J |
en |
dc.contributor.author |
Tonkin, A |
en |
dc.contributor.author |
Wilcken, D |
en |
dc.contributor.author |
Murphy, J |
en |
dc.contributor.author |
Cleverly, Y |
en |
dc.date.accessioned |
2018-11-05T22:44:23Z |
en |
dc.date.issued |
2002 |
en |
dc.identifier.citation |
European Heart Journal, 2002, 23 pp. 1509 - 1515 (7) |
en |
dc.identifier.issn |
0195-668X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43956 |
en |
dc.description.abstract |
Aims To determine the effects on homocysteine levels of two doses of folic acid compared to placebo, where the high dose is typical of that provided by pharmacological intervention and the low dose approximates that provided by dietary supplementation. Methods and Results The PACIFIC study was a doubleblind, placebo-controlled, factorial randomized trial. Seven hundred and twenty-three individuals with a history of myocardial infarction or unstable angina were recruited from 28 clinical cardiology centres in Australia and New Zealand and randomized to folic acid 2·0 mg daily, folic acid 0·2 mg daily or placebo. The primary outcome, homocysteine, was measured using a fluorescence polarization immunoassay. Compared to placebo, 2·0mg folic acid reduced homocysteine by 1·8 mol . l 1 [95% confidence interval (CI) 1·3– 2·3] and 0·2 mg reduced homocysteine by 1·2 mol . l 1 (95% CI 0·8–1·7). The higher dose reduced homocysteine significantly more than the lower dose (P=0·01). Conclusions Both doses of folic acid reduced homocysteine, but the effects of the 2·0 mg dose were about one third greater than the 0·2 mg dose. Fortification of foods with folic acid should result in population-wide lower levels of homocysteine but high-dose pharmacological supplementation would produce greater reductions for high-risk individuals. |
en |
dc.publisher |
Oxford University Press (OUP) |
en |
dc.relation.ispartofseries |
European Heart Journal |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Dose-dependent effects of folic acid on plasma homocysteine in a randomized trial conducted among 723 individuals with coronary heart disease |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1053/euhj.2002.3161 |
en |
pubs.issue |
19 |
en |
pubs.begin-page |
1509 |
en |
pubs.volume |
23 |
en |
dc.identifier.pmid |
12395803 |
en |
pubs.author-url |
http://eurheartj.oxfordjournals.org/content/ehj/23/19/1509.full.pdf |
en |
pubs.end-page |
1515 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
32902 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
dc.identifier.eissn |
1522-9645 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
12395803 |
en |