dc.contributor.author |
Macdonald, NP |
en |
dc.contributor.author |
Zhu, F |
en |
dc.contributor.author |
Hall, Christopher |
en |
dc.contributor.author |
Reboud, J |
en |
dc.contributor.author |
Crosier, Philip |
en |
dc.contributor.author |
Patton, EE |
en |
dc.contributor.author |
Wlodkowic, D |
en |
dc.contributor.author |
Cooper, JM |
en |
dc.date.accessioned |
2018-11-05T22:54:20Z |
en |
dc.date.issued |
2016-01 |
en |
dc.identifier.citation |
Lab on a chip 16(2):291-297 Jan 2016 |
en |
dc.identifier.issn |
1473-0197 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43962 |
en |
dc.description.abstract |
3D printing has emerged as a rapid and cost-efficient manufacturing technique to enable the fabrication of bespoke, complex prototypes. If the technology is to have a significant impact in biomedical applications, such as drug discovery and molecular diagnostics, the devices produced must be biologically compatible to enable their use with established reference assays and protocols. In this work we demonstrate that we can adapt the Fish Embryo Test (FET) as a new method to quantify the toxicity of 3D printed microfluidic devices. We assessed the biocompatibility of four commercially available 3D printing polymers (VisiJetCrystal EX200, Watershed 11122XC, Fototec SLA 7150 Clear and ABSplus P-430), through the observation of key developmental markers in the developing zebrafish embryos. Results show all of the photopolymers to be highly toxic to the embryos, resulting in fatality, although we do demonstrate that post-printing treatment of Fototec 7150 makes it suitable for zebrafish culture within the FET. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Lab on a chip |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/3.0/ |
en |
dc.rights.uri |
https://www.rsc.org/journals-books-databases/open-access/gold-open-access/ |
en |
dc.subject |
Animals |
en |
dc.subject |
Zebrafish |
en |
dc.subject |
Polymers |
en |
dc.subject |
Biocompatible Materials |
en |
dc.subject |
Microfluidic Analytical Techniques |
en |
dc.subject |
Toxicity Tests |
en |
dc.subject |
Photochemical Processes |
en |
dc.subject |
Printing, Three-Dimensional |
en |
dc.title |
Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1039/c5lc01374g |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
291 |
en |
pubs.volume |
16 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
26646354 |
en |
pubs.end-page |
297 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
515056 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1473-0189 |
en |
pubs.record-created-at-source-date |
2015-12-10 |
en |
pubs.dimensions-id |
26646354 |
en |