Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.

Show simple item record Govindpani, Karan en Calvo-Flores Guzmán, Beatriz en Vinnakota, Chitra en Waldvogel, Henry en Faull, Richard en Kwakowsky, Andrea en 2018-11-05T23:23:59Z en 2017-08-21 en
dc.identifier.issn 1422-0067 en
dc.identifier.uri en
dc.description.abstract γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain. In the past, there has been a major research drive focused on the dysfunction of the glutamatergic and cholinergic neurotransmitter systems in Alzheimer's disease (AD). However, there is now growing evidence in support of a GABAergic contribution to the pathogenesis of this neurodegenerative disease. Previous studies paint a complex, convoluted and often inconsistent picture of AD-associated GABAergic remodeling. Given the importance of the GABAergic system in neuronal function and homeostasis, in the maintenance of the excitatory/inhibitory balance, and in the processes of learning and memory, such changes in GABAergic function could be an important factor in both early and later stages of AD pathogenesis. Given the limited scope of currently available therapies in modifying the course of the disease, a better understanding of GABAergic remodeling in AD could open up innovative and novel therapeutic opportunities. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries International journal of molecular sciences en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.subject Brain en
dc.subject Humans en
dc.subject Alzheimer Disease en
dc.subject gamma-Aminobutyric Acid en
dc.subject Neurotransmitter Agents en
dc.subject GABAergic Neurons en
dc.title Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease. en
dc.type Journal Article en
dc.identifier.doi 10.3390/ijms18081813 en
pubs.issue 8 en
pubs.volume 18 en
dc.rights.holder Copyright: The authors en
dc.identifier.pmid 28825683 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype review-article en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 653490 en Academic Services en Examinations en Medical and Health Sciences en Medical Sciences en Anatomy and Medical Imaging en
dc.identifier.eissn 1422-0067 en
pubs.record-created-at-source-date 2017-08-22 en
pubs.dimensions-id 28825683 en

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