dc.contributor.author |
Govindpani, Karan |
en |
dc.contributor.author |
Calvo-Flores Guzmán, Beatriz |
en |
dc.contributor.author |
Vinnakota, Chitra |
en |
dc.contributor.author |
Waldvogel, Henry |
en |
dc.contributor.author |
Faull, Richard |
en |
dc.contributor.author |
Kwakowsky, Andrea |
en |
dc.date.accessioned |
2018-11-05T23:23:59Z |
en |
dc.date.issued |
2017-08-21 |
en |
dc.identifier.issn |
1422-0067 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/43981 |
en |
dc.description.abstract |
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain. In the past, there has been a major research drive focused on the dysfunction of the glutamatergic and cholinergic neurotransmitter systems in Alzheimer's disease (AD). However, there is now growing evidence in support of a GABAergic contribution to the pathogenesis of this neurodegenerative disease. Previous studies paint a complex, convoluted and often inconsistent picture of AD-associated GABAergic remodeling. Given the importance of the GABAergic system in neuronal function and homeostasis, in the maintenance of the excitatory/inhibitory balance, and in the processes of learning and memory, such changes in GABAergic function could be an important factor in both early and later stages of AD pathogenesis. Given the limited scope of currently available therapies in modifying the course of the disease, a better understanding of GABAergic remodeling in AD could open up innovative and novel therapeutic opportunities. |
en |
dc.format.medium |
Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
International journal of molecular sciences |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1661-6596/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
en |
dc.subject |
Brain |
en |
dc.subject |
Humans |
en |
dc.subject |
Alzheimer Disease |
en |
dc.subject |
gamma-Aminobutyric Acid |
en |
dc.subject |
Neurotransmitter Agents |
en |
dc.subject |
GABAergic Neurons |
en |
dc.title |
Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.3390/ijms18081813 |
en |
pubs.issue |
8 |
en |
pubs.volume |
18 |
en |
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
28825683 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
review-article |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
653490 |
en |
pubs.org-id |
Academic Services |
en |
pubs.org-id |
Examinations |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
dc.identifier.eissn |
1422-0067 |
en |
pubs.record-created-at-source-date |
2017-08-22 |
en |
pubs.dimensions-id |
28825683 |
en |