Natural history of corneal haze after corneal collagen crosslinking in keratoconus using Scheimpflug analysis.

Show simple item record Kim, Bia Z en Jordan, Charlotte A en McGhee, Charles en Patel, Dipika en 2018-11-05T23:40:38Z en 2016-07 en
dc.identifier.issn 0886-3350 en
dc.identifier.uri en
dc.description.abstract PURPOSE:To analyze corneal haze after corneal collagen crosslinking (CXL) for progressive keratoconus using Scheimpflug densitometry. SETTING:Auckland District Health Board, Auckland, New Zealand. DESIGN:Prospective randomized controlled study. METHODS:Both eyes of all patients were examined preoperatively and 1, 3, 6, and 12 months postoperatively. One eye of each patient was treated with corneal CXL, with the contralateral eye serving as the control. Examinations included uncorrected distance visual acuity and corrected distance visual acuity (CDVA), slitlamp biomicroscopy, and Scheimpflug tomography (Pentacam). RESULTS:Thirty-six eyes of 36 patients were enrolled. The mean preoperative corneal densitometry was 19.0 ± 3.2 (SD). Postoperatively, the mean densitometry peaked at 1 month, decreasing to baseline level after 6 months without application of topical corticosteroids. The development of haze was significant compared with the contralateral untreated eyes (P < .01). The anterior (120 μm) and inner (central 0.0 to 2.0 mm) zones of the cornea had the highest densitometry after treatment. Lower preoperative central corneal thickness (CCT) was significantly correlated with higher corneal densitometry (P = .03). However, the preoperative CCT, keratometry, and astigmatism did not influence the difference in densitometry between the treated eyes and untreated eyes. There was no evidence of a relationship between densitometry and CDVA (P = .30). CONCLUSIONS:After corneal CXL, patients with keratoconus developed transient corneal haze in the anterior central cornea that might not require specific treatment. Thin corneas were associated with higher densitometry; thus, there might be a greater expectancy of corneal haze in patients with advanced keratoconus. FINANCIAL DISCLOSURE:None of the authors has a financial or proprietary interest in any material or method mentioned. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Journal of cataract and refractive surgery en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Corneal Stroma en
dc.subject Humans en
dc.subject Keratoconus en
dc.subject Collagen en
dc.subject Riboflavin en
dc.subject Photosensitizing Agents en
dc.subject Cross-Linking Reagents en
dc.subject Corneal Topography en
dc.subject Photochemotherapy en
dc.subject Prospective Studies en
dc.subject Ultraviolet Rays en
dc.title Natural history of corneal haze after corneal collagen crosslinking in keratoconus using Scheimpflug analysis. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jcrs.2016.04.019 en
pubs.issue 7 en
pubs.begin-page 1053 en
pubs.volume 42 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 27492105 en
pubs.end-page 1059 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Randomized Controlled Trial en
pubs.subtype Journal Article en
pubs.elements-id 540009 en Medical and Health Sciences en School of Medicine en Ophthalmology Department en
dc.identifier.eissn 1873-4502 en
pubs.record-created-at-source-date 2016-08-06 en
pubs.dimensions-id 27492105 en

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