dc.contributor.author |
Vaidyanathan, Venkatesh |
en |
dc.contributor.author |
Naidu, Vijay |
en |
dc.contributor.author |
Karunasinghe, Wannakuwattewaduge |
en |
dc.contributor.author |
Kao, Chi Hsiu-Juei |
en |
dc.contributor.author |
Pallati, Radha |
en |
dc.contributor.author |
Jabed, Anower |
en |
dc.contributor.author |
Ferguson, Lynnette |
en |
dc.contributor.author |
Kallingappa, Prasanna |
en |
dc.contributor.author |
Ferguson, Lynnette R |
en |
dc.date.accessioned |
2018-11-06T21:51:35Z |
en |
dc.date.issued |
2017-09 |
en |
dc.identifier.issn |
1742-206X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/44051 |
en |
dc.description.abstract |
Prostate cancer is one of the most significant male health concerns worldwide, and various researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. Single nucleotide polymorphisms are increasingly becoming strong biomarker candidates to identify the susceptibility of individuals to prostate cancer. We carried out risk association of different stages of prostate cancer to a number of single nucleotide polymorphisms to identify the susceptible alleles in a New Zealand population and checked the interaction with environmental factors as well. We identified a number of single nucleotide polymorphisms to have associations specifically to the risk of prostate cancer and aggressiveness of the disease, and also certain single nucleotide polymorphisms to be vulnerable to the reported behavioral factors. We have addressed "special" environmental conditions prevalent in New Zealand, which can be used as a model for a bigger worldwide study. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Molecular bioSystems |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Prostatic Neoplasms |
en |
dc.subject |
Genetic Predisposition to Disease |
en |
dc.subject |
Risk Factors |
en |
dc.subject |
Aging |
en |
dc.subject |
Genotype |
en |
dc.subject |
Polymorphism, Single Nucleotide |
en |
dc.subject |
Alleles |
en |
dc.subject |
New Zealand |
en |
dc.subject |
Male |
en |
dc.title |
Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1039/c7mb00203c |
en |
pubs.issue |
10 |
en |
pubs.begin-page |
1967 |
en |
pubs.volume |
13 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
28783191 |
en |
pubs.end-page |
1980 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
648109 |
en |
pubs.org-id |
Academic Services |
en |
pubs.org-id |
Examinations |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
pubs.org-id |
Molecular Medicine |
en |
dc.identifier.eissn |
1742-2051 |
en |
pubs.record-created-at-source-date |
2017-08-08 |
en |
pubs.dimensions-id |
28783191 |
en |