dc.contributor.author |
Segovia, Stephanie A |
en |
dc.contributor.author |
Vickers, Mark |
en |
dc.contributor.author |
Gray, Clint |
en |
dc.contributor.author |
Zhang, Xiaoyuan D |
en |
dc.contributor.author |
Reynolds, Clare |
en |
dc.date.accessioned |
2018-11-07T01:47:02Z |
en |
dc.date.issued |
2017-07-27 |
en |
dc.identifier.citation |
Scientific Reports 7(1):6663-undefined 27 Jul 2017 |
en |
dc.identifier.issn |
2045-2322 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/44059 |
en |
dc.description.abstract |
The developmental origins of health and disease hypothesis proposes that an adverse early life environment, including in utero exposure to a maternal obesogenic environment, can lead to an increased long-term risk of obesity and related metabolic complications in offspring. We assessed whether maternal supplementation with conjugated linoleic acid (CLA) could prevent some of these adverse effects in offspring exposed to a maternal high fat diet. Sprague-Dawley dams consumed either a: control (CD), control with CLA (CLA), high fat (HF) or high fat with CLA (HFCLA) diet 10 days prior to mating and throughout pregnancy/lactation. Male offspring were weaned onto a standard chow diet. Body composition was quantified by DXA and oral glucose tolerance tests conducted on adult offspring. Gene/protein expression and histological analysis were conducted in adipose tissue. Offspring from HF dams had increased body weight, body fat deposition, impaired insulin sensitivity and adipocyte hypertrophy; all of which were rescued in HFCLA offspring. Molecular and histological analyses of the adipose tissue suggest that disturbances in adipogenesis may mediate the metabolic dysfunction observed in HF offspring. Therefore, CLA supplementation to a maternal obesogenic diet may be a promising strategy to prevent adverse programming outcomes. |
en |
dc.format.medium |
Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Scientific reports |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
en |
dc.subject |
Adipose Tissue |
en |
dc.subject |
Animals |
en |
dc.subject |
Rats |
en |
dc.subject |
Rats, Sprague-Dawley |
en |
dc.subject |
Obesity |
en |
dc.subject |
Linoleic Acids, Conjugated |
en |
dc.subject |
Dietary Supplements |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Maternal Nutritional Physiological Phenomena |
en |
dc.subject |
Diet, High-Fat |
en |
dc.title |
Conjugated Linoleic Acid Supplementation Improves Maternal High Fat Diet-Induced Programming of Metabolic Dysfunction in Adult Male Rat Offspring. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1038/s41598-017-07108-9 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
6663 |
en |
pubs.volume |
7 |
en |
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
28751679 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
644676 |
en |
pubs.org-id |
Liggins Institute |
en |
dc.identifier.eissn |
2045-2322 |
en |
pubs.record-created-at-source-date |
2017-07-29 |
en |
pubs.dimensions-id |
28751679 |
en |