dc.contributor.author |
Sneyd, A |
en |
dc.contributor.author |
Means, Shawn |
en |
dc.contributor.author |
Zhu, Di |
en |
dc.contributor.author |
Rugis, John |
en |
dc.contributor.author |
Won, Jong Hak |
en |
dc.contributor.author |
Yule, David I |
en |
dc.date.accessioned |
2018-11-07T21:29:01Z |
en |
dc.date.issued |
2017-04 |
en |
dc.identifier.citation |
Journal of Theoretical Biology 419:383-393 21 Apr 2017 |
en |
dc.identifier.issn |
0022-5193 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/44072 |
en |
dc.description.abstract |
We construct a model of calcium waves in a three-dimensional anatomically accurate parotid acinar cell, constructed from experimental data. Gradients of inositol trisphosphate receptor (IPR) density are imposed, with the IPR density being greater closer to the lumen, which has a branched structure, and inositol trisphosphate (IP3) is produced only at the basal membrane. We show (1) that IP3 equilibrates so quickly across the cell that it can be assumed to be spatially homogeneous; (2) spatial separation of the sites of IP3 action and IP3 production does not preclude the formation of stable oscillatory Ca2+ waves. However, these waves are not waves in the mathematical sense of a traveling wave with fixed profile. They result instead from a time delay between the Ca2+ rise in the apical and basal regions; (3) the ryanodine receptors serve to reinforce the Ca2+ wave, but are not necessary for the wave to exist; (4) a spatially independent model is not sufficient to study saliva secretion, although a one-dimensional model might be sufficient. Our results here form the first stages of the construction of a multiscale and multicellular model of saliva secretion in an entire acinus. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Journal of theoretical biology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://www.elsevier.com/about/policies/sharing |
en |
dc.subject |
Parotid Gland |
en |
dc.subject |
Saliva |
en |
dc.subject |
Animals |
en |
dc.subject |
Humans |
en |
dc.subject |
Calcium |
en |
dc.subject |
Inositol 1,4,5-Trisphosphate |
en |
dc.subject |
Ryanodine Receptor Calcium Release Channel |
en |
dc.subject |
Calcium Signaling |
en |
dc.subject |
Ion Transport |
en |
dc.subject |
Algorithms |
en |
dc.subject |
Models, Biological |
en |
dc.subject |
Computer Simulation |
en |
dc.subject |
Inositol 1,4,5-Trisphosphate Receptors |
en |
dc.subject |
Acinar Cells |
en |
dc.title |
Modeling calcium waves in an anatomically accurate three-dimensional parotid acinar cell. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.jtbi.2016.04.030 |
en |
pubs.begin-page |
383 |
en |
pubs.volume |
419 |
en |
dc.rights.holder |
Copyright: Elsevier Ltd |
en |
dc.identifier.pmid |
27155044 |
en |
pubs.end-page |
393 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.subtype |
Research Support, N.I.H., Extramural |
en |
pubs.elements-id |
527637 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Mathematics |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1095-8541 |
en |
pubs.record-created-at-source-date |
2016-05-08 |
en |
pubs.dimensions-id |
27155044 |
en |