High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling.

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dc.contributor.author Stephenson, Robert S en
dc.contributor.author Atkinson, Andrew en
dc.contributor.author Kottas, Petros en
dc.contributor.author Perde, Filip en
dc.contributor.author Jafarzadeh, Fatemeh en
dc.contributor.author Bateman, Mike en
dc.contributor.author Iaizzo, Paul A en
dc.contributor.author Zhao, Jichao en
dc.contributor.author Zhang, Henggui en
dc.contributor.author Anderson, Robert H en
dc.contributor.author Jarvis, Jonathan C en
dc.contributor.author Dobrzynski, Halina en
dc.date.accessioned 2018-11-12T20:55:47Z en
dc.date.issued 2017-08-03 en
dc.identifier.citation Scientific Reports 7:13 pages Article number 7188 03 Aug 201 en
dc.identifier.issn 2045-2322 en
dc.identifier.uri http://hdl.handle.net/2292/44135 en
dc.description.abstract Cardiac arrhythmias and conduction disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction system. Here, using contrast enhanced micro-computed tomography, we present, in attitudinally appropriate fashion, the first 3-dimensional representations of the cardiac conduction system within the intact human heart. We show that cardiomyocyte orientation can be extracted from these datasets at spatial resolutions approaching the single cell. These data show that commonly accepted anatomical representations are oversimplified. We have incorporated the high-resolution anatomical data into mathematical simulations of cardiac electrical depolarisation. The data presented should have multidisciplinary impact. Since the rate of depolarisation is dictated by cardiac microstructure, and the precise orientation of the cardiomyocytes, our data should improve the fidelity of mathematical models. By showing the precise 3-dimensional relationships between the cardiac conduction system and surrounding structures, we provide new insights relevant to valvar replacement surgery and ablation therapies. We also offer a practical method for investigation of remodelling in disease, and thus, virtual pathology and archiving. Such data presented as 3D images or 3D printed models, will inform discussions between medical teams and their patients, and aid the education of medical and surgical trainees. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries Scientific reports en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Heart Conduction System en
dc.subject Bundle of His en
dc.subject Purkinje Fibers en
dc.subject Sinoatrial Node en
dc.subject Humans en
dc.subject Contrast Media en
dc.subject Imaging, Three-Dimensional en
dc.subject Image Enhancement en
dc.subject Models, Theoretical en
dc.subject Models, Anatomic en
dc.subject X-Ray Microtomography en
dc.title High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling. en
dc.type Journal Article en
dc.identifier.doi 10.1038/s41598-017-07694-8 en
pubs.issue 1 en
pubs.begin-page 7188 en
pubs.volume 7 en
dc.rights.holder Copyright: The authors en
dc.identifier.pmid 28775383 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 649565 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
dc.identifier.eissn 2045-2322 en
pubs.record-created-at-source-date 2017-08-05 en
pubs.dimensions-id 28775383 en

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