A systematic review of primary outcomes and outcome measure reporting in randomized trials evaluating treatments for pre-eclampsia.

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dc.contributor.author Duffy, James MN en
dc.contributor.author Hirsch, Martin en
dc.contributor.author Gale, Chris en
dc.contributor.author Pealing, Louise en
dc.contributor.author Kawsar, Anusuya en
dc.contributor.author Showell, Marian en
dc.contributor.author Williamson, Paula R en
dc.contributor.author Khan, Khalid S en
dc.contributor.author Ziebland, Sue en
dc.contributor.author McManus, Richard J en
dc.contributor.author International Collaboration to Harmonize Outcomes for Pre-eclampsia (iHOPE) en
dc.date.accessioned 2018-11-12T22:00:46Z en
dc.date.issued 2017-12 en
dc.identifier.citation International Journal of Gynecology and Obstetrics 139(3):262-267 Dec 2017 en
dc.identifier.issn 0020-7292 en
dc.identifier.uri http://hdl.handle.net/2292/44141 en
dc.description.abstract BACKGROUND:An evaluation of outcome reporting is required to develop a core outcome set. OBJECTIVES:To assess primary outcomes and outcome measure reporting in pre-eclampsia trials. SEARCH STRATEGY:Five online databases were searched from inception to January 2016 using terms including "preeclampsia" and "randomized controlled trial". SELECTION CRITERIA:Randomized controlled trials evaluating treatments for pre-eclampsia published in any language were included. DATA COLLECTION AND ANALYSIS:Primary outcomes and data on outcome measure reporting were systematically extracted and categorized. MAIN RESULTS:Overall, 79 randomized trials including data from 31 615 women were included. Of those, 38 (48%) reported 35 different primary outcomes; 28 were maternal outcomes and seven were fetal/neonatal outcomes. Three randomized trials reported composite outcomes, incorporating between six and nine outcome components. The method of definition or measurement was infrequently or poorly reported. Even when outcomes were consistent across trials, different methods of definition or measurement were frequently described. CONCLUSIONS:In randomized trials evaluating interventions for pre-eclampsia, critical information related to the primary outcome, including definition and measurement, is regularly omitted. Developing a core outcome set for pre-eclampsia trials would help to inform primary outcome selection and outcome measure reporting. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html en
dc.subject International Collaboration to Harmonize Outcomes for Pre-eclampsia (iHOPE) en
dc.subject Humans en
dc.subject Pre-Eclampsia en
dc.subject Pregnancy en
dc.subject Research Design en
dc.subject Female en
dc.subject Randomized Controlled Trials as Topic en
dc.subject Outcome Assessment, Health Care en
dc.title A systematic review of primary outcomes and outcome measure reporting in randomized trials evaluating treatments for pre-eclampsia. en
dc.type Journal Article en
dc.identifier.doi 10.1002/ijgo.12298 en
pubs.issue 3 en
pubs.begin-page 262 en
pubs.volume 139 en
dc.rights.holder Copyright: International Federation of Gynecology and Obstetrics en
dc.identifier.pmid 28803445 en
pubs.end-page 267 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Systematic Review en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 653308 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Obstetrics and Gynaecology en
dc.identifier.eissn 1879-3479 en
pubs.record-created-at-source-date 2017-08-14 en
pubs.dimensions-id 28803445 en

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