Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model.

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dc.contributor.author Wang, Tao en
dc.contributor.author Dang, Gengting en
dc.contributor.author Guo, Zhaoqing en
dc.contributor.author Yang, Min en
dc.date.accessioned 2018-11-13T02:46:21Z en
dc.date.issued 2005-07 en
dc.identifier.issn 1076-3279 en
dc.identifier.uri http://hdl.handle.net/2292/44171 en
dc.description.abstract Autologous bone marrow mesenchymal stem cell (BMSC)-calcium phosphate ceramic composites were constructed in vitro and implanted as a bone graft substitute for lumbar anterior interbody fusion in rhesus monkeys to determine the osteogenic capacity of the composites. Nine adult rhesus monkeys underwent lumbar L3-L4 and L5-L6 diskectomy and interbody fusion via an anterior retroperitoneal approach. Two fusion sites in each animal were randomly assigned to two of three treatments: autogenous tricortical iliac crest bone graft (autograft group), cell-free ceramic graft (ceramic group), or BMSC-ceramic composite graft (BMSC group). Autologous BMSCs were expanded in culture and stimulated with osteogenic supplement. The spinal fusion segments were evaluated by radiography, biomechanical testing, histologic analysis, and histomorphometric analysis 3 months postsurgery. The BMSC group achieved lumbar interbody fusion superior to that of the ceramic group, both biomechanically and histologically. The BMSC group and the autograft group showed equivalent biomechanical stiffness. Ceramic residues were significantly greater in the ceramic group versus the BMSC group. The results indicate that BMSC-ceramic composites can enhance bone regeneration and achieve osseous spinal fusion 3 months after implantation in the rhesus monkey interbody fusion model. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Tissue engineering en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Lumbar Vertebrae en
dc.subject Animals en
dc.subject Macaca mulatta en
dc.subject Disease Models, Animal en
dc.subject Calcium Phosphates en
dc.subject Bone Substitutes en
dc.subject Ceramics en
dc.subject Treatment Outcome en
dc.subject Spinal Fusion en
dc.subject Bone Marrow Transplantation en
dc.subject Mesenchymal Stem Cell Transplantation en
dc.subject Female en
dc.subject Male en
dc.subject Intervertebral Disc Displacement en
dc.title Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model. en
dc.type Journal Article en
dc.identifier.doi 10.1089/ten.2005.11.1159 en
pubs.issue 7-8 en
pubs.begin-page 1159 en
pubs.volume 11 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 16144452 en
pubs.end-page 1167 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Evaluation Studies en
pubs.subtype Journal Article en
pubs.elements-id 680599 en
dc.identifier.eissn 1557-8690 en
pubs.record-created-at-source-date 2005-09-07 en
pubs.dimensions-id 16144452 en

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