Comparison of readout-segmented echo-planar imaging (EPI) and single-shot EPI in clinical application of diffusion-weighted imaging of the pediatric brain.

Show simple item record Yeom, Kristen W en Holdsworth, Samantha en Van, Anh T en Iv, Michael en Skare, Stefan en Lober, Robert M en Bammer, Roland en 2018-11-13T23:25:45Z en 2013-05 en
dc.identifier.citation American Journal of Roentgenology 200(5):W437-W443 May 2013 en
dc.identifier.issn 0361-803X en
dc.identifier.uri en
dc.description.abstract Readout-segmented echo-planar imaging (EPI) has been suggested as an alternative to single-shot EPI for diffusion-weighted imaging (DWI) with reduced distortion. However, clinical comparisons of readout-segmented EPI and EPI DWI are limited by unmatched imaging parameters and reconstruction procedures. Our goal was to compare the clinical utility of generalized autocalibrating partial parallel acquisition (GRAPPA)-accelerated readout-segmented EPI DWI with GRAPPA-accelerated EPI DWI for visualization of the pediatric brain in regions prone to distortion, such as the orbit, skull base, and posterior fossa.Thirty consecutive patients (mean age, 7.8 years) presenting with orbital, skull base, and posterior fossa neuropathologic abnormalities were scanned at 3 T. Images were obtained using GRAPPA-accelerated readout-segmented EPI and GRAPPA-accelerated EPI with an identical scanning time, acceleration factor, target resolution, and image postprocessing procedure. The two datasets were independently reviewed by two blinded neuroradiologists. Imaging studies were evaluated for resolution, signal-to-noise ratio (SNR), contrast, distortion, lesion conspicuity, and diagnostic confidence and graded using a 7-point Likert scale (1, nondiagnostic; 7, outstanding).There was good reader agreement in the scores (κ = 0.66; 95% CI, 0.54-0.78). The mean scores for EPI and readout-segmented EPI, respectively, were as follows: resolution, 5.0 and 6.0; SNR, 5.5 and 3.0; contrast, 3.7 and 3.2; distortion, 4.8 and 6.0; lesion conspicuity, 4.6 and 5.1; and diagnostic confidence, 4.7 and 5.4. Readout-segmented EPI was superior in resolution, distortion reduction, lesion conspicuity, and diagnostic confidence, whereas EPI scored better in SNR and contrast. Readout-segmented EPI was considered the better sequence overall in 85% of the cases.This study shows the benefits of improved resolution and reduced distortion of readout-segmented EPI in evaluating the orbit, skull base, and posterior fossa, sites of common neuropathologic abnormalities in children. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries AJR. American journal of roentgenology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Brain en
dc.subject Humans en
dc.subject Brain Diseases en
dc.subject Echo-Planar Imaging en
dc.subject Image Enhancement en
dc.subject Sensitivity and Specificity en
dc.subject Reproducibility of Results en
dc.subject Adolescent en
dc.subject Child en
dc.subject Child, Preschool en
dc.subject Infant en
dc.subject Infant, Newborn en
dc.subject Female en
dc.subject Male en
dc.subject Young Adult en
dc.title Comparison of readout-segmented echo-planar imaging (EPI) and single-shot EPI in clinical application of diffusion-weighted imaging of the pediatric brain. en
dc.type Journal Article en
dc.identifier.doi 10.2214/ajr.12.9854 en
pubs.issue 5 en
pubs.begin-page W437 en
pubs.volume 200 en
dc.rights.holder Copyright: American Roentgen Ray Society en
dc.identifier.pmid 23617511 en
pubs.end-page W443 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Comparative Study en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Evaluation Studies en
pubs.subtype Journal Article en
pubs.subtype Research Support, N.I.H., Extramural en
pubs.elements-id 683327 en Medical and Health Sciences en Medical Sciences en Anatomy and Medical Imaging en
dc.identifier.eissn 1546-3141 en
pubs.record-created-at-source-date 2013-04-26 en
pubs.dimensions-id 23617511 en

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